성균관대학교 분자독성학연구실

1997.03 ~ 2001.12	국립독성연구원 독성부
2006. 01 ~ 2007. 12	대한약학회 학술간사
2013. 03 ~ 2016. 12	환경독성보건학회 학술위원장/부회장
2013. 01 ~ 2014. 12	한국독성학회/발암원학회 학술위원장
2013. 03 ~	식품위생안전성학회 이사
2015.01 ~ 2018.12	대한약학회 사업위원장
2018.01 ~ 2019.12	한국독성학회/발암원학회 사무총장
2019.01 ~ 2022.12	대한약학회 총무위원장
2023. 01 ~	한국독성학회/발암원학회 수석부회장
2023.01 ~	대한약학회 사무총장

Differential susceptibility of neonates and adults to temperature and methylmercury in the marine rotifer Brachionus plicatilis. J. Hazard. Mater. 2023. (in press). (IF, 13.6)	Jeong H, Lee JS, Kim HS, Lee JS.
Combined exposure to hypoxia and nanoplastics leads to negative synergistic oxidative stress-mediated effects in the water Flea Daphnia magna. J. Hazard Mater. 2023, 1025:189745. (IF,13.6)	Lee JS, Oh Y, Lee JS, Kim HS.
Synergistic toxic mechanisms of microplastics and triclosan via multixenobiotic resistance (MXR) inhibition-mediated autophagy in the freshwater water flea Daphnia magna. Sci. Total Environ. 2023, 896:165214. (IF,10.725)	Lee JS, Oh Y, Park HE, Lee JS, Kim HS.
Dendropanoxide Alleviates Thioacetamide-induced Hepatic Fibrosis via Inhibition of ROS Production and Inflammation in BALB/C Mice. Int. J. Biol. Sci. 2023,19(9):2630-2647. (IF,10.750)	Kundu A, Gali S, Sharma S, Kacew S, Yoon S, Jeong HG, Kwak JH, Kim HS.
Protective effect of dendropanoxide against cadmium-induced hepatotoxicity via anti-inflammatory activities in Sprague-Dawley rats. Toxicol. Mech. Methods, 2023 30:1-15. (IF, 3.3)	Gali S, Sharma S, Kundu A, Lee E, Han JH, Shin JK, Choi JS, Kyung SY, Kim JS, Kim HS.
Fibrinogen on extracellular vesicles derived from polyhexamethylene guanidine phosphate-exposed mice induces inflammatory effects via integrin β. Ecotoxicol. Environ. Safety, 2023, 252:114600. (IF, 6.8)	Kim JW, Jeong MH, Yu HT, Park YJ, Kim HS, Chung KH.
Acute toxicity, oxidative stress, and apoptosis due to short-term triclosan exposure and multi- and transgenerational effects on in vivo endpoints, antioxidant defense, and DNA damage response in the freshwater water flea Daphnia magna. Sci. Total. Environ. 2023, 864:160925. (IF, 10.725)	Lee JS, Oh Y, Lee JS, Kim HS.
Anti-inflammatory effect and metabolic mechanism of BS012, a mixture of Asarum sieboldii, Platycodon grandiflorum, and Cinnamomum cassia extracts, on atopic dermatitis in vivo and in vitro. Phytomedicine. 2023 Jul:115:154818. (IF, 7.9)	Lee G, Park J, Lee H, Kim KS, Park JH, Kyung SY, Kim HS, Yang HO, Jung BH.
Chlorophyll a and novel synthetic derivatives alleviate atopic dermatitis by suppressing Th2 cell differentiation via IL-4 receptor modulation. Clin. Immunol. 2023 Nov 27:109852. (IF,8.6)	Kang KM, Han JH, Kim KS, Kim EK, Shin Y, Park JH, Kim H, Kim NY, Kim YG, Kim H, Park H, Kim YM, Kee SJ, Kim SJ, Kim HS, Kim YC.
Apocynin abrogates methotrexate-induced nephrotoxicity: role of TLR4/NF-κB-p65/p38-MAPK, IL-6/STAT-3, PPAR-γ, and SIRT1/ FOXO3 signaling pathways. Arch. Pharm. Res. 2023 Apr;46(4):339-359. (IF,6.7)	Hassanein EHM, Sayed AM, El-Ghafar OAMA, Omar ZMM, Rashwan EK, Mohammedsaleh ZM, Kyung SY, Park JH, Kim HS, Ali FEM
Sesamin ameliorates lipotoxicity and lipid accumulation through the activation of the estrogen receptor alpha signaling pathway. Biochem. Pharmacol. 2023 Oct:216: 115768. (IF,5.8)	Pham TH, Lee GH, Jin SW, Lee SY, Han EH, Kim ND, Choi CY, Jeong GS, Ki Lee S, Kim HS, Jeong HG.
Cationic nanoplastic causes mitochondrial dysfunction in neural progenitor cells and impairs hippocampal neurogenesis. Free Radic. Biol. Med. 2023 Nov 1:208:194-210. (IF,7.4)	Yang S, Lee S, Lee Y, Cho JH, Kim SH, Ha ES, Jung YS, Chung HY, Kim MS, Kim HS, Chang SC, Min KJ, Lee J.
Anticancer effects of the HDAC inhibitor, 3β,6β‑dihydroxyurs‑12‑en‑27‑oic acid, in MCF‑7 breast cancer cells via the inhibition of Akt/mTOR pathways. Oncol. Rep. 2023 Feb;49(2):43. (IF,4.2)	Lim JS, Kyung SY, Jeon Y, Kim IS, Kwak JH, Kim HS.
Polystyrene microplastic particles induce autophagic cell death in BEAS-2B human bronchial epithelial cells. Environ. Toxicol. 2023 Feb;38(2):359-367. (IF,4.5)	Jeon MS, Kim JW, Han YB, Jeong MH, Kim HR, Sik Kim H, Park YJ, Chung KH.
Physiologically based pharmacokinetic modelling to predict pharmacokinetics of enavogliflozin, a sodium-dependent glucose transporter inhibitor, in humans. Pharmaceutics 2023, 15(3):942.	Kim MS, Song YK, Choi JS, Ji HY, Yang E, Park JS, Kim HS, Kim MJ, Cho IK, Chung SJ, Chae YJ, Lee KR.
Metallothionein 3 inhibits 3T3-L1 adipocyte differentiation 2 via reduction of reactive oxygen species. Antioxidants 2023, 12(3): 640.	Li Y, Lee SH, Piao M, Kim HS, Lee KY.
Pyruvate Kinase M2: A New Biomarker for the Early Detection of Diabetes-Induced Nephropathy. Int. J. Mol. Sci. 2023, 24(3):2683.	Park YS, Han JH, Park JH, Choi JS, Kim SH, Kim HS.
Risk Assessment and Risk Reduction of Ptaquiloside in Bracken Fern. Toxics. 2023, 11(2):115.	Kim MK, Kang JS, Kundu A, Kim HS, Lee BM.
Synthesis and evaluation of ent-Conduramine C-1 derivatives as α-glucosidase inhibitors via CSI-mediated amination reaction. Carbohydr. Res. 2023;524:108746.	Park GM, Kong SJ, Park JH, Kang JE, An SH, Kim HS, Kim IS, Boggu PR, Jung YH.
Dendropanoxide attenuates high glucose-induced oxidative damage in NRK-52E cells via AKT/mTOR signaling pathway. Planta Medica. 2023.	Song Hee Lee, Ju Ri Kim, Joo Kyung Shin, Jin-Sol Lee, YM Kim, kwak Jong Hwan, HS Kim.
Low-dose Pimecrolimus, an FDA-approved Calcineurin Inhibitor, Sensitizes Drug-resistant Cancer Cells via Strong P-gp Inhibition. ANTICANCER RESEARCH . 43: 1103-1112 (2023)	JAE HYEON PARK, JI SUN LEE, JOO KYUNG SHIN, SWATI SHARMA, HYUNG SIK KIM and SUNGPIL YOON.
Rashwan5 ·Apocynin abrogates methotrexate‑induced nephrotoxicity: role of TLR4/NF‑κB‑p65/p38‑MAPK, IL‑6/STAT‑3, PPAR‑γ, and SIRT1/FOXO3 signaling pathways. Archives of Pharmacal Research (2023) 46:339–359	Emad H. M. Hassanein1 · Ahmed M. Sayed2 · Omnia A. M. Abd El‑Ghafar3 · Zainab M. M. Omar4 · Eman K.
An integrated 1 in vitro approach to identifying chemically induced oxidative stress and toxicity in mitochondria.	Donghyun Kima, Yusun Shina, Hyung Sik Kimb, Kyung-Hwa Parkc and Ok-Nam Bae a
Sesamin ameliorates lipotoxicity and lipid accumulation through the activation of the estrogen receptor alpha signaling pathway. Biochemical Pharmacology 216 (2023) 115768	Pham TH, Lee GH, Jin SW, Lee SY, Han EH, Kim ND, Choi CY, Jeong GS, Lee SK, Kim HS, Jeong HG.
Cationic nanoplastic causes mitochondrial dysfunction in neural progenitor cells and impairs hippocampal neurogenesis. Free Radical Biology and Medicine 208 (2023) 194–210	Yang S, Lee S, Lee Y, Cho JH, Kim SH, Ha ES, Jung YS, Chung HY, Kim MS, Kim HS, Chang SC, Min KJ, Lee J.
Physiological effects and molecular response in the marine rotifer Brachionus plicatilis after combined exposure to nanoplastics and copper Marine Pollution Bulletin 194 (2023) 115332.	Wang C, Jeong H, Lee JS, Maszczyk P, Alaa El-Din H. Sayed, Hwang UK, Kim HS, Lee JS, Eunjin Byeon E.
First-Line Combination Treatment with Low-Dose Bipolar Drugs for ABCB1-Overexpressing Drug-Resistant Cancer Populations. Int. J. Mol. Sci. 2023, 24, 8389.	Yoon S, Kim HS.
Low‑dose curcumin enhances hippocampal neurogenesis and memory retention in young mice. Archives of Pharmacal Research. 2023.	Lee Y, Park HR, Lee JY, Kim J, Yang S, Lee C, Kim K, Kim HS, Chang SC, Lee J.

Glycolytic Metabolic Remodeling by the Truncate of Glioma-Associated Oncogene Homolog 1 in Triple-Negative Breast Cancer Cells. J. Cancer 2022,13(10):3031-3043.(IF, 3.9)	Lee SH, Lee JS, Park JH, Yoon S, Lee KY, Kim HS.
Reprograming lung epithelial cells by decrease of miR-451a in extracellular vesicles contribute to aggravation of fibrosis. Cell. Biol. Toxicol. 2022, 38(5)725-740. (IF,6.1)	Jeong MH, Kim HR, Park YJ, Chung KH, Kim HS.
Menin Enhances Androgen Receptor-Independent Proliferation and Migration of Prostate Cancer Cells. Mol. Cells. 2022 Apr 30;45(4):202-215. (IF,3.8)	Kim T, Jeong K, Kim E, Yoon K, Choi J, Park JH, Kim JH, Kim HS, Youn HD, Cho EJ.
Tenovin-1 Ameliorates Renal Fibrosis in High-Fat-Diet-Induced Diabetic Nephropathy via Antioxidant and Anti-Inflammatory Pathways. Antioxidants (Basel). 2022 Sep 14;11(9):1812. (IF, 7.4)	Kundu A, Gali S, Sharma S, Park JH, Kyung SY, Kacew S, Kim IS, Lee KY, Kim HS.
Using intracellular metabolic profiling to identify novel biomarkers of cisplatin-induced acute kidney injury in NRK-52E cells. J. Toxicol. Environ. Health A. 2022 Jan 2;85(1):29-42. (IF, 2.6)	Kim HR, Park JH, Lee SH, Kwack SJ, Lee J, Kim S, Yoon S, Kim KB, Lee BM, Kacew S, Kim HS.
Micro-ultrasonic Assessment of Early Stage Clot Formation and Whole Blood Coagulation Using an All-Optical Ultrasound Transducer and Adaptive Signal Processing Algorithm. ACS Sens. 2022 Oct 28;7(10):2940-2950. (IF,8.9)	Biswas D, Heo J, Sang P, Dey P, Han K, Ko JH, Won SM, Son D, Suh M, Kim HS, Ok JG, Park HJ, Baac HW.
Functional and dynamic mitochondrial damage by chloromethylisothiazolinone/ methylisothiazolinone (CMIT/MIT) mixture in brain endothelial cell lines and rat cerebrovascular endothelium. Toxicol Lett. 2022 Aug 1:366:45-57. (IF,3.5)	Kim D, Shin Y, Kim EH, Lee Y, Kim S, Kim HS, Kim HC, Leem JH, Kim HR, Bae ON.
YY2 Promotes Osteoblast Differentiation by Upregulating Osterix Transcriptional Activity. Int. J. Mol. Sci. 2022, 23(8):4303.	Piao M, Lee SH, Kim MJ, Kim HS, Lee KY.
Synthesis of Succinimide-Linked Indazol-3-ols Derived from Maleimides under Rh(III) Catalysis. ACS Omega. 2022, 7(17):14712-14722.	Kang JY, Kim S, Moon J, Chung E, Kim J, Kyung SY, Kim HS, Mishra NK, Kim IS.
AT9283, 1-Cyclopropyl-3-(3-(5-(Morpholinomethyl)-1H-Benzo[d]Imidazole-2-yl)-1H-Pyrazol-4-yl) Urea, Inhibits Syk to Suppress Mast Cell-Mediated Allergic Response. Biomol. Ther. (Seoul) 2022, 30(6):520-528.	Kim SJ, Choi MY, Min KY, Jo MG, Kim JM, Kim HS, Kim YM.
Physiologically based pharmacokinetic (PBPK) modeling of flurbiprofen in different CYP2C9 genotypes. Arch. Pharm. Res. 2022, 45(8):584-595.	Whang SS, Cho CK, Jung EH, Kang P, Park HJ, Lee YJ, Choi CI, Bae JW, Kim HS, Jang CG, Lee SY.
Di- n-butyl phthalate disrupts neuron maturation in primary rat embryo neurons and male C57BL/6 mice. J. Toxicol. Environ.Health part A. 2022, 85(2):56-70.	Lee S, Lee W, Yang S, Suh YJ, Hong DG, Chang SC, Kim HS, Lee J.
Physiologically based pharmacokinetic (PBPK) modeling of piroxicam with regard to CYP2C9 genetic polymorphism. Arch. Pharm. Res. 2022, 45(5):352-366.	Cho CK, Kang P, Park HJ, Ko E, Mu CY, Lee YJ, Choi CI, Kim HS, Jang CG, Bae JW, Lee SY.
Low-Dose Rifabutin Increases Cytotoxicity in Antimitotic-Drug-Treated Resistant Cancer Cells by Exhibiting Strong P-gp-Inhibitory Activity. Int. J. Mol. Sci. 2022, 23(13):7383.	Lee JS, Oh Y, Kim HS, Yoon S.
Physiologically based pharmacokinetic modelling to predict the pharmacokinetics of metoprolol in different CYP2D6 genotypes. Arch. Pharm. Res. 2022,45(6):433-445.	Lee CM, Kang P, Cho CK, Park HJ, Lee YJ, Bae JW, Choi CI, Kim HS, Jang CG, Lee SY.
Ruthenium(II)-Catalyzed Tandem C-H Allylation and [3 + 2] Dipolar Cycloaddition to Construct Bridged Tetracycles. Org. Lett. 2022, 24(44):8115-8119.	Moon J, Ko N, Jang S, Ghosh P, Kim HS, Mishra NK, Kim IS.
Combination Treatment Using Pyruvate Kinase M2 Inhibitors for the Sensitization of High Density Triple-negative Breast Cancer Cells. In Vivo. 2022, 36(5):2105-2115.	Lee JS, Oh Y, Lee JS, Park JH, Shin JK, Han JH, Kim HS, Yoon S.
Terconazole, an Azole Antifungal Drug, Increases Cytotoxicity in Antimitotic Drug-Treated Resistant Cancer Cells with Substrate-Specific P-gp Inhibitory Activity. Int. J. Mol. Sci. 2022, 23(22):13809.	Lee JS, Oh Y, Park JH, Kyung SY, Kim HS, Yoon S.
PKM2 Is Overexpressed in Glioma Tissues, and Its Inhibition Highly Increases Late Apoptosis in U87MG Cells With Low-density Specificity. In Vivo. 2022, 36(2):694-703.	Park JH, Lee JS, Oh Y, Lee JS, Park HE, Lee H, Park YS, Kyung SY, Kim HS, Yoon S.
JAK2 Inhibitor, Fedratinib, Inhibits P-gp Activity and Co-Treatment Induces Cytotoxicity in Antimitotic Drug-Treated P-gp Overexpressing Resistant KBV20C Cancer Cells. Int. J. Mol. Sci. 2022, 23(9):4597	Oh Y, Lee JS, Lee JS, Park JH, Kim HS, Yoon S.
Novel Specific Pyruvate Kinase M2 Inhibitor, Compound 3h, Induces Apoptosis and Autophagy through Suppressing Akt/mTOR Signaling Pathway in LNCaP Cells. Cancers (Basel). 2022,15(1):265	Jiang C, Zhao X, Jeong T, Kang JY, Park JH, Kim IS, Kim HS.
Co-treatment of Low Dose Pacritinib, a Phase III Jak2 Inhibitor, Greatly Increases Apoptosis of P-gp Over-expressing Cancer Cells With Multidrug Resistance. Anticancer Res. 2022,42(5):2433-2442.	Oh Y, Lee JS, Lee JS, Park JH, Kim HS, Yoon S.

Potential protective roles of curcumin against cadmium-induced toxicity and oxidative stress.

J. Toxicol. Environ. Health B Crit Rev. 2021, 24(3):95-118.(IF, 8.4)

Park JH, Lee BM, Kim HS.Park JH, Lee BM, Kim HS.

Chemopreventive effects of Melastoma malabathricum L. extract in mammary tumor model via inhibition of oxidative stress and
inflammatory cytokines.

Biomed Pharmacother 2021,137:111298.(IF, 7.5)

Kumar V, Sachan R, Rahman M, Rub RA, Patel DK, Sharma K, Gahtori P,Kumar V, Sachan R, Rahman M, Rub RA, Patel DK, Sharma K, Gahtori PAl-Abbasi FA, Alhayyani S, Anwar F, Kim HS.

Specific Pyruvate Kinase M2 Inhibitor, Compound 3K, Induces Autophagic Cell Death through Disruption of the Glycolysis Pathway
in Ovarian Cancer Cells.

Int. J. Biol Sci. 2021, 17(8): 1895-1908. (IF,10.725).

Park JH, Kundu A, Lee SH, Jiang C, Lee SH, Kim YS, Kyung SY, Park SH, Kim HS.Park JH, Kundu A, Lee SH, Jiang C, Lee SH, Kim YS, Kyung SY, Park SH, Kim HS.

Phytopharmaceuticals mediated Furin and TMPRSS2 receptor blocking: can it be a potential therapeutic option for Covid-19?.

Phytomedicine. 2021; 85:153396.

Palit P, Chattopadhyay D, Thomas S, Kundu A, Kim HS, Rezaei N.Palit P, Chattopadhyay D, Thomas S, Kundu A, Kim HS, Rezaei N.

Transition-Metal-Free Alkylation and Acylation of Benzoxazinones with 1,4-Dihydropyridines.

J. Org. Chem. 2021; 86(17):12247-12256.

Byun Y, Moon J, An W, Mishra NK, Kim HS, Ghosh P, Kim IS.Byun Y, Moon J, An W, Mishra NK, Kim HS, Ghosh P, Kim IS.

Di- n-butyl phthalate disrupts neuron maturation in primary rat embryo neurons and male C57BL/6 mice.

J Toxicol Environ Health A. 2022 Jan 17;85(2):56-70.

Lee S, Lee W, Yang S, Suh YJ, Hong DG, Chang SC,
Kim HS, Lee J.Lee S, Lee W, Yang S, Suh YJ, Hong DG, Chang SC, Kim HS, Lee J.

Identification of Novel Biomarker for Early Detection of Diabetic Nephropathy.

Biomedicines. 2021;9(5):457.

Kim KS, Lee JS, Park JH, Lee EY, Moon JS, Lee SK,
Lee JS, Kim JH, Kim HS.Kim KS, Lee JS, Park JH,
Lee EY, Moon JS, Lee SK, Lee JS, Kim JH, Kim HS.

Current status and future directions of hepatocellular carcinoma-targeted nanoparticles and nanomedicine.

Expert Opin Drug Deliv. 2021;18(6):673-694.

Kumar V, Rahman M, Gahtori P, Al-Abbasi F, Anwar F, Kim HS.Kumar V, Rahman M, Gahtori P, Al-Abbasi F, Anwar F, Kim HS.

Effects of tobacco compound 4-(methylnitrosamino) -1-(3-pyridyl)-1-butanone (NNK) on the expression of epigenetically
regulated genes in lung carcinogenesis.

J Toxicol Environ Health A. 2021;84(24):1004-1019.

Jin SW, Im JS, Park JH, Kim HG, Lee GH, Kim SJ, Kwack SJ, Kim KB, Chung KH, Lee BM, Kacew S, Jeong HG, Kim HS.Jin SW, Im JS, Park JH, Kim HG, Lee GH, Kim SJ, Kwack SJ, Kim KB, Chung KH, Lee BM, Kacew S, Jeong HG, Kim HS.

Sensitization Effects of Repurposed Blood Pressure-regulating Drugs on Drug-resistant Cancer Cells.

Anticancer Res. 2021;41(12):6179-6190.

Jiang C, Zheng T, Park JH, Lee JS, Oh Y, Kundu A,

Kim HS, Yoon S.

Synthesis of spirosuccinimides via annulative cyclization between N-aryl indazolols and maleimides under rhodium(III) catalysis.

Chem Commun (Camb). 2021,19;57(83):10947-10950.

Kang JY, An W, Kim S, Kwon NY, Jeong T, Ghosh P,

Kim HS, Mishra NK, Kim IS.

Secondary Metabolites from the Leather Coral-Derived Fungal Strain Xylaria sp. FM1005 and Their Glycoprotein IIb/IIIa Inhibitory Activity.

J Nat Prod. 2021;84(2):466-473.

Zaman KAU, Park JH, DeVine L, Hu Z, Wu X, Kim HS,

Cao S.

Chemopreventive effects of Melastoma malabathricum L. extract in mammary tumor model via inhibition of oxidative stress and

inflammatory cytokines.

Biomed Pharmacother. 2021:137:111298.

Kumar V, Sachan R, Rahman M, Rub RA, Patel DK,

Sharma K, Gahtori P, Al-Abbasi FA, Alhayyani S,

Anwar F, Kim HS.

Specific Pyruvate Kinase M2 Inhibitor, Compound 3K, Induces Autophagic Cell Death through Disruption of the Glycolysis Pathway in

Ovarian Cancer Cells.

Int J Biol Sci. 2021;17(8):1895-1908.

Park JH, Kundu A, Lee SH, Jiang C, Lee SH, Kim YS, Kyung SY, Park SH, Kim HS.Park JH, Kundu A, Lee SH, Jiang C, Lee SH, Kim YS, Kyung SY, Park SH, Kim HS.

TGF- β1 can be regulated by NDRG2 via the NF-κB pathway in hypoxia-induced liver fibrosis.

Ann. Transl. Med. 2021;9(6):505.

Ba HZ, Liang ZH, Kim HS, Cao W.Ba HZ, Liang ZH, Kim HS, Cao W.

Correction to Antibacterial and NF-κB Inhibitory Lumazine Peptides, Aspochalasin, γ-Butyrolactone Derivatives, and

Cyclic Peptides from a Hawaiian Aspergillus flavipes.

J Nat Prod. 2021;84(6):1861.

Wang C, Wu X, Bai H, Uz Zaman KA, Hou S, Saito J, Wongwiwatthananukit S, Kim HS, Cao S.

A Low Dose of Aripiprazole Has the Strongest Sensitization Effect Among 19 Repositioned Bipolar Drugs in P-gp-overexpressing

Drug-resistant Cancer Cells.

Anticancer Res. 2021;41(2):687-697.

Jiang C, Lee SH, Park JH, Lee JS, Park JW, Kim JR, Lee SH, Kim HS, Yoon S.

Transition-Metal-Free Alkylation and Acylation of Benzoxazinones with 1,4-Dihydropyridines.

J. Org. Chem. 2021, 86(17):12247-12256.

Byun Y, Moon J, An W, Mishra NK, Kim HS, Ghosh P, Kim IS.

Secondary Metabolites from the Leather Coral-Derived Fungal Strain Xylaria sp. FM1005 and Their Glycoprotein IIb/IIIa Inhibitory Activity.

J. Nat. Prod. 2021, 26;84(2):466-473.

Ahammad K, Zaman U, Park JH, DeVine L, Hu Z,
Wu X, Kim HS, Cao S.

Toxico-metabolomics study of a deep eutectic solvent comprising choline chloride and urea suggests in vivo toxicity involving oxidative stress

and ammonia stress.

Green Chemistry. 2021; 23, 1300–1311.

Jung D, Jung, JB, Kang S, Li K, Hwang I, Jeong JH, Kim HS, Lee J.

Quercetin and Isorhamnetin Attenuate Benzo[a]pyrene-Induced Toxicity by Modulating Detoxification Enzymes through the AhR
and NRF2 Signaling Pathways.

Antioxidants 2021, 10(5):787.

Kim M, Jee SC, Kim KS, Kim HS, Yu KN, Sung JS.

Protective effects of Croton hookeri on streptozotocin-induced diabetic nephropathy. Food Chem. Toxicol. 2020, 135:110873.	Kundu A, Dey P, Sarkar P, Karmakar S, Tae IH, Kim KS, Park JH, Lee SH, Lee BM, Renthlei L, Puia Z, Kim HS.
Biological Evaluation of Oxindole Derivative as a Novel Anticancer Agent against Human Kidney Carcinoma Cells. Biomolecules. 2020, 10(9):1260.	Dey P, Kundu A, Han SH, Kim KS, Park JH, Yoon S, Kim IS, Kim HS.
Antibacterial and NF-κB Inhibitory Lumazine Peptides, Aspochalasin, γ‑Butyrolactone Derivatives, and Cyclic Peptides from a Hawaiian Aspergillus flavipes. J. Nat. Product. 2020, 84(6):1861.	Cong Wang, Xiaohua Wu, Helong Bai, KH Ahammad Uz Zaman, Shaobin Hou, Jennifer Saito, Supakit Wongwiwatthananukit, Hyung Sik Kim, and Shugeng Cao.
Protective Effects of Quercetin and Isorhamnetin against Benzo[a]pyrene-Induced 8-Hydroxy-2’-Deoxyguanosine and BPDE-DNA Adduct Formation. Antioxidants (Basel). 2020	Kim M, Jee SC, Kim KS, Kim HS, Yu KN, Sung JS.
Detoxifying effects of optimal hyperoxia (40% oxygenation) exposure on benzo[a]pyrene-induced toxicity in human keratinocytes. J. Toxicol. Environ. Health A. 2020 Jan 17;83(2):82-94.	Kwon CY, Kim HS, Lee BM.
Dendropanax morbifera Protects against Renal Fibrosis in Streptozotocin-Induced Diabetic Rats. Antioxidants 2020 Jan 19;9(1):84.	Sachan R, Kundu A, Dey P, Son JY, Kim KS, Lee DE, Kim HR, Park JH, Lee SH, Kim JH, Cao S, Lee BM, Kwak JH, Kim HS.
Phthalazinone-Assisted C-H Amidation Using Dioxazolones Under Rh(III) Catalysis. J. Org. Chem. 2020 Jun 5;85(11):7014-7023.	Jeoung D, Kim K, Han SH, Ghosh P, Lee SH, Kim S, An W, Kim HS, Mishra NK, Kim IS.
Risk assessment of unintentional phthalates contaminants in cosmetics. Regul. Toxicol. Pharmacol. 2020;115:104687.	Kim MK, Kim KB, Yoon S, Kim HS, Lee BM.
Protective effects of dendropanoxide isolated from Dendropanax morbifera against cisplatin-induced acute kidney injury via the AMPK/mTOR signaling pathway. Food Chem Toxicol. 2020;145:111605.	Park YJ, Kim KS, Park JH, Lee SH, Kim HR, Lee SH, Choi HB, Cao S, Kumar V, Kwak JH, Kim HS.
Protective Effects of Myricetin on Benzo[a]pyrene-Induced 8-Hydroxy-2'-Deoxyguanosine and BPDE-DNA Adduct. Antioxidants (Basel). 2020;9(5):446.	Jee SC, Kim M, Kim KS, Kim HS, Sung JS.
Protective effect of EX-527 against high-fat diet-induced diabetic nephropathy in Zucker rats. Toxicol. Appl. Pharmacol. 2020;390:114899.	Kundu A, Richa S, Dey P, Kim KS, Son JY, Kim HR, Lee SY, Lee BH, Lee KY, Kacew S, Lee BM, Kim HS.
Adverse health risk from prolonged consumption of formaldehyde-preserved carps in eastern region of Indian population. Environ. Sci. Pollut. Res. Int. 2020; 27(14):16415-16425.	Kundu A, Dey P, Bera R, Sarkar R, Kim B, Kacew S, Lee BM, Karmakar S, Kim HS.
EX-527 Prevents the Progression of High-Fat Diet-Induced Hepatic Steatosis and Fibrosis by Upregulating SIRT4 in Zucker Rats. Cells. 2020; 9(5):1101.	Kundu A, Dey P, Park JH, Kim IS, Kwack SJ, Kim HS.
Integration of transcriptomics, proteomics and metabolomics identifies biomarkers for pulmonary injury by polyhexamethylene guanidine phosphate (PHMG-p), a humidifier disinfectant, in rats. Arch. Toxicol. 2020; 94(3):887-909.	Lee JD, Kim HY, Kang K, Jeong HG, Song MK, Tae IH, Lee SH, Kim HR, Lee K, Chae S, Hwang D, Kim S, Kim HS, Kim KB, Lee BM.
Low-Dose Crizotinib, a Tyrosine Kinase Inhibitor, Highly and Specifically Sensitizes P-Glycoprotein-Overexpressing Chemoresistant Cancer Cells Through Induction of Late Apoptosis in vivo and in vitro. Front. Oncol. 2020;10:696.	Kim KS, Jiang C, Kim JY, Park JH, Kim HR, Lee SH, Kim HS, Yoon S.
A new SIRT1 inhibitor, MHY2245, induces autophagy and inhibits energy metabolism via PKM2/mTOR pathway in human ovarian cancer cells. Int. J. Biol. Sci. 2020;16(11):1901-1916.	Tae IH, Son JY, Lee SH, Ahn MY, Yoon K, Yoon S, Moon HR, Kim HS.
A New Histone Deacetylase Inhibitor, MHY4381, Induces Apoptosis via Generation of Reactive Oxygen Species in Human Prostate Cancer Cells. Biomol. Ther. (Seoul). 2020;28(2):184-194.	Richa S, Dey P, Park C, Yang J, Son JY, Park JH, Lee SH, Ahn MY, Kim IS, Moon HR, Kim HS.

Extracts from Paeonia lactiflora Pallas, Rehmannia Glutinosa var. Purpurea Makino, Perilla Frutescens var. Acuta Kudo may increase the endometrial receptivity through expression of leukemia inhibitory factor and adhesion molecules. J. Tradit. Chin. Med. 2019;39(1):15-25.	Eun-Yeong K, Tae-Wook C, Hee-Jung C, Ki-Tae H, Yeon-Seop J, Syng-Ook L, Jun-Yong C, Hyung Sik K, Sooseong Y, Myeong Soo L.
Ruthenium(II)-Catalyzed Site-Selective Hydroxymethylation of Indolines with Paraformaldehyde. J. Org. Chem. 2019;84(4):2307-2315.	Lee SH, Jeong T, Kim K, Kwon NY, Pandey AK, Kim HS, Ku JM, Mishra NK, Kim IS.
Risk Assessment of 5-Chloro-2-Methylisothiazol-3(2H)-One/2-Methylisothiazol-3(2H)-One (CMIT/MIT) Used as a Preservative in Cosmetics. Toxicol. Res. 2019;35(2):103-117.	Kim MK, Kim KB, Lee JY, Kwack SJ, Kwon YC, Kang JS, Kim HS, Lee BM.
Therapeutic value of steroidal alkaloids in cancer: Current trends and future perspectives. Int J Cancer. 2019 Oct 1;145(7):1731-1744.	Dey P, Kundu A, Chakraborty HJ, Kar B, Choi WS, Lee BM, Bhakta T, Atanasov AG, Kim HS.
Risk assessment of phthalates in pharmaceuticals. J Toxicol Environ Health A. 2019;82(5):351-360.	Chung BY, Choi SM, Roh TH, Lim DS, Ahn MY, Kim YJ, Kim HS, Lee BM.
Plumbagin from a tropical pitcher plant (Nepenthes alata Blanco) induces apoptotic cell death via a p53-dependent pathway in MCF-7 human breast cancer cells. Food Chem Toxicol. 2019 Jan;123:492-500.	De U, Son JY, Jeon Y, Ha SY, Park YJ, Yoon S, Ha KT, Choi WS, Lee BM, Kim IS, Kwak JH, Kim HS.
Protective effects of Croton hookeri on streptozotocin-induced diabetic nephropathy. Food Chem Toxicol. 2020 Jan;135:110873.	Kundu A, Dey P, Sarkar P, Karmakar S, Tae IH, Kim KS, Park JH, Lee SH, Lee BM, Renthlei L, Puia Z, Kim HS.
Dendropanax morbifera Ameliorates Thioacetamide-Induced Hepatic Fibrosis via TGF-β1/Smads Pathways. Int J Biol Sci. 2019 Feb 13;15(4):800-811.	Yang HY, Kim KS, Lee YH, Park JH, Kim JH, Lee SY, Kim YM, Kim IS, Kacew S, Lee BM, Kwak JH, Yoon K, Kim HS.
Protective Effects of Dendropanax morbifera against Cisplatin-Induced Nephrotoxicity without Altering Chemotherapeutic Efficacy. Antioxidants (Basel).2019 Jul 30;8(8):256.	Kim JS, Kim KS, Son JY, Kim HR, Park JH, Lee SH, Lee DE, Kim IS, Lee KY, Lee BM, Kwak JH, Kim HS.
Estrogen Deficiency Potentiates Thioacetamide-Induced Hepatic Fibrosis in Sprague-Dawley Rats. Int J Mol Sci. 2019 Jul 29;20(15):3709.	Lee YH, Son JY, Kim KS, Park YJ, Kim HR, Park JH, Kim KB, Lee KY, Kang KW, Kim IS, Kacew S, Lee BM, Kim HS.
Detoxification effects of aloe polysaccharide and propolis on the urinary excretion of metabolites in smokers. Food Chem Toxicol. 2019 Aug;130:99-108.	Koo HJ, Lee KR, Kim HS, Lee BM.
Curcumin Ameliorates Benzo[a]pyrene-Induced DNA Damages in Stomach Tissues of Sprague-Dawley Rats. Int J Mol Sci. 2019 Nov 6;20(22):5533.	Kim KS, Kim NY, Son JY, Park JH, Lee SH, Kim HR, Kim B, Kim YG, Jeong HG, Lee BM, Kim HS.
Knockdown of Pyruvate Kinase M2 Inhibits Cell Proliferation, Metabolism, and Migration in Renal Cell Carcinoma. Int J Mol Sci. 2019 Nov 10;20(22):5622.	Dey P, Son JY, Kundu A, Kim KS, Lee Y, Yoon K, Yoon S, Lee BM, Nam KT, Kim HS.
Tyrosine Kinase Inhibitors Imatinib and Erlotinib Increase Apoptosis of Antimitotic Drug-resistant KBV20C Cells Without Inhibiting P-gp. Anticancer Res. 2019 Jul;39(7):3785-3793.	Kim JY, Kim HS, Yoon S.
An Anti-Cancer Drug Candidate CYC116 Suppresses Type I Hypersensitive Immune Responses through the Inhibition of Fyn Kinase in Mast Cells. Biomol Ther (Seoul). 2019 May 1;27(3):311-317.	Park YH, Kim HW, Kim HS, Nam ST, Lee D, Lee MB, Min KY, Koo J, Kim SJ, Kim YM, Kim HS, Choi WS.
Quantitative structure-activity and quantitative structure-property relationship approaches as alternative skin sensitization risk assessment methods. J Toxicol Environ Health A. 2019;82(7):447-472. doi: 10.1080/15287394.2019.1616437.	Kim JY, Kim MK, Kim KB, Kim HS, Lee BM.
PKM2 Knockdown Induces Autophagic Cell Death via AKT/mTOR Pathway in Human Prostate Cancer Cells. Cell. Physiol. Biochem. 2019;52(6):1535-1552.	Dey P, Kundu A, Sachan R, Park JH, Ahn MY, Yoon K, Lee J, Kim ND, Kim IS, Lee BM, Kim HS.
Alternative skin sensitization prediction and risk assessment using proinflammatory biomarkers, interleukin-1 beta (IL-1β) and inducible nitric oxide synthase (iNOS). J Toxicol Environ Health A. 2019;82(5):361-378.	Kim MK, Kim KB, Kim HS, Lee BM.

Advances in toxicological research and risk assessment.

J Toxicol Environ Health A. 2018;81(11):383.

Lee BM, Kim HS, Chun YJ.

Ruthenium(II)-Catalyzed Site-Selective Hydroxymethylation of Indolines with Paraformaldehyde.

J Org Chem. 2019 Feb 15;84(4):2307-2315.

Lee SH, Jeong T, Kim K, Kwon NY, Pandey AK, Kim HS, Ku JM, Mishra NK, Kim IS.

Curcumin ameliorates cadmium-induced nephrotoxicity in Sprague-Dawley rats.

Food Chem. Toxicol., 114: 34-40, 2018.

Kim KS, Lim HJ, Lim JS, Son JY, Lee J, Lee BM, Chang SC, Kim HS.

Afrocyclamin A, a triterpenoid saponin induces apoptosis and autophagy cell death via PI3k/Akt/mTOR and p38MAPK/JNK pathway in
human prostate cancer cells.

Phytomedicine, 2018; 51:139-150.

Richa S, De U, Park YJ, Lee BM, Kim HS.

Determination of fragrance allergens and their dermal sensitization quantitative risk assessment (QRA) in 107 spray perfumes.

J. Toxicol. Environ. Health A. 2018;81(22):1173-1185.

Lim DS, Choi SM, Kim KB, Yoon K, Kacew S, Kim HS, Lee BM.

Risk assessment of endocrine disrupting phthalates and hormonal alterations in children and adolescents.

J. Toxicol. Environ. Health A. 2018;81(21):1150-1164.

Hyun Kim D, Min Choi S, Soo Lim D, Roh T, Jun Kwack S, Yoon S, Kook Kim M, Sil Yoon K, Sik Kim H, Wook Kim D, Lee BM.

Alkyl chain-modified cyclometalated iridium complexes as tunable anticancer and imaging agents.

Dalton Trans. 2018;47(44):15873-15881.

Laha P, De U, Chandra F, Dehury N, Khullar S, Kim HS, Patra S.

Novel therapeutic roles of MC-4 in combination with everolimus against advanced renal cell carcinoma by dual targeting of Akt/pyruvate
kinase muscle isozyme M2 and mechanistic target of rapamycin complex 1 pathways.

Cancer Med. 2018; doi: 10.1002/cam4.1748.

Son JY, Yoon S, Tae IH, Park YJ, De U, Jeon Y, Park YJ, Rhyu IJ, Lee BM, Chung KH, Lim JE, Lee SJ, Lee HW, Kwak JH, Kim HS, Choi HY.

IL-1α and IL-1β as alternative biomarkers for risk assessment and the prediction of skin sensitization potency.

J. Toxicol. Environ. Health A. 2018;81(17):830-843.

Kim MK, Kim KB, Yoon K, Kacew S, Kim HS, Lee BM.

Potential repositioning of GV1001 as a therapeutic agent for testosterone‑induced benign prostatic hyperplasia.

Int. J. Mol. Med. 2018, 42(4):2260-2268.

Kim KS, Yang HY, Chang SC, Kim YM, Lee KY, Lee BM, Kim HS.

Dual Role of Anthranils as Amination and Transient Directing Group Sources: Synthesis of 2-Acyl Acridines.

Org. Lett. 2018, 20(13):4010-4014.

Kim S, Han SH, Mishra NK, Chun R, Jung YH, Kim HS, Park JS, Kim IS.

Inhibition of di(2-ethylhexyl) phthalate (DEHP)-induced endocrine disruption by co-treatment of vitamins C and E and their mechanism of action.

J. Toxicol. Environ. Health A. 2018, 81(16):748-760.

Choi SM, Lim DS, Kim MK, Yoon S, Kacew S, Kim HS, Lee BM.

Risk assessment of benzalkonium chloride in cosmetic products.

J. Toxicol. Environ. Health B Crit Rev. 2018, 21(1):8-23.

Choi SM, Roh TH, Lim DS, Kacew S, Kim HS, Lee BM.

Repositioningofanti-cancerdrugcandidate,AZD7762,toananti-allergicdrugsuppressingIgE-mediatedmastcellsandallergicresponsesviatheinhibitionofLynandFyn.

Biochem. Pharmacol. 154:270-277, 2018.

ParkYH, KimDK, KimHW, KimHS, LeeD, LeeMB, YoungMinK, KooJ, KimSJ, KangC, MiKimY ,KimHS ,ChoiWS.

Risk assessment of N-nitrosodiethylamine (NDEA) and N-nitrosodiethanolamine (NDELA) in cosmetics.

J Toxicol Environ Health A. 81(12):465-480, 2018.

Lim DS, Roh TH, Kim MK, Kwon YC, Choi SM,
Kwack SJ, Kim KB, Yoon S, Kim HS, Lee BM.

Advances in toxicological research and risk assessment.

J. Toxicol. Environ. Health A. 81(11):383, 2018.

Lee BM, Kim HS, Chun YJ.

P-gp Inhibition by the Anti-psychotic Drug Pimozide Increases Apoptosis, as well as Expression of pRb and pH2AX in
Highly Drug-resistant KBV20C Cells.

Anticancer Res. 2018, 38(10):5685-5692.

Kim JY, Park Y, Lee BM, Kim HS, Yoon S.

Novel SIRT1 inhibitor 15-deoxy-Δ12,14-prostaglandin J2 and its derivatives exhibit anticancer activity through apoptotic or
autophagic cell death pathways in SKOV3 cells.

Int. J. Oncol., 2018, 53: 2518-2530.

Tae IH, Park EY, Dey P, Son JY, Lee SY, Jung JH,

Saloni S, Kim MH, Kim HS.

A New Synthetic Histone Deacetylase Inhibitor, MHY2256, Induces Apoptosis and Autophagy Cell Death in Endometrial Cancer Cells
via p53 Acetylation.

Int. J. Mol. Sci. 2018 13;19(9). pii: E2743.

De U, Son JY, Sachan R, Park YJ, Kang D, Yoon K,
Lee BM, Kim IS, Moon HR, Kim HS.

Aging-related Repositioned Drugs, Donepezil and Sildenafil Citrate, Increase Apoptosis of Anti-mitotic Drug-resistant KBV20C Cells Through Different Molecular Mechanisms.

Anticancer Res. 2018,38(9):5149-5157.

Kim JY, Son JY, Lee BM, Kim HS, Yoon S.

Low Doses of the Anti-psychotic Drug Aripiprazole Have Strong P-gp-inhibitory Activity and Sensitize Anti-mitotic Drug-resistant Cancer Cells.

Anticancer Res. 2018, 38(9):5101-5108.

Kim JY, Tae IH, Lee BM, Kim HS, Yoon S.

Reactivity of Morita-Baylis-Hillman Adducts in C-H Functionalization of (Hetero)aryl Nitrones: Access to Bridged Cycles and Carbazoles.

Org Lett. 2018, 20(15):4632-4636.

Pandey AK, Kang D, Han SH, Lee H, Mishra NK,
Kim HS, Jung YH, Hong S, Kim IS.

Reduction in prevalence of hypertension and blood heavy metals among Curry-consumed Korean.

Tohoku J. Exp. Med., 2018, 244(3): 219-229.

Choi JW, Oh C, Shim SY, Jeong S, Kim HS, Kim MS.

Synthesis of (2H)-Indazoles through Rh(III)-Catalyzed Annulation Reaction of Azobenzenes with Sulfoxonium Ylides.

The Journal of Organic Chemistry, 2018, 83(7):4070-4077.

Oh H, Han S, Pandey AK, Han SH, Mishra NK, Kim S, Chun R, Kim HS, Park J, Kim IS.

Synthesis of TMPA Derivatives through Sequential Ir(III)-Catalyzed C−H Alkylation and Their Antidiabetic Evaluation.

ACS OMEGA, 2018, 3: 2661-2672.

Lee SH, Kundu A, Han SH, Mishra N, Kim KS,
Choi MH, Pandy AK, Park JS, Kim HS, Kim IS.

Detoxifying effect of pyridoxine on acetaminophen-induced hepatotoxicity via suppressing oxidative stress injury.

Food Chem. Toxicol, 114: 11-22, 2018.

Roh TH, Lim SK, De U, Bang DH, Kim MK, Seo HS, Choi SM, Lim DS, Kacew S, Kim HS, Lee BM.

Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing claudin-1 overexpression in podocytes.

Toxicol. Lett., 2018.

Kundu A, Sachan R, Lee BM, Kim HS.

Non-cancer, cancer, and dermal sensitization risk assessment of heavy metals in cosmetics.

J Toxicol Environ Health A. 2018;81(11):432-452.

Lim DS, Roh TH, Kim MK, Kwon YC, Choi SM,
Kwack SJ, Kim KB, Yoon S, Kim HS, Lee BM.

Hepatic damage exacerbates cisplatin-induced acute kidney injury in Sprague-Dawley rats.

J. Toxicol. Environ. Health A, 2018; 81(11):397-407.

Kim JS, SON JY, Kim KS, Lim HJ, Ahn MY, Kwack SJ, Kim YM, Lee BM, Kim HS.

Formation and inhibition of N-nitrosodiethanolamine in cosmetics under pH, temperature, and fluorescent, ultraviolet, and visual light.

J. Toxicol. Environ. Health A, 2018;81(9):241-253.

Lim DS, Lim SK, Kim MK, Kwon YC, Roh TH, Choi SM, Yoon S, Kim HS, Lee BM.

Learning, memory deficits, and impaired neuronal maturation attributed to acrylamide.

J. Toxicol. Environ. Health A, 2018;81(9):254-265.

Lee S, Park HR, Lee JY, Cho JH, Song HM, Kim AH,
Lee W, Lee Y, Chang SC, Kim HS, Lee J.

Evaluation of subchronic exposure to triclosan on hepatorenal and reproductive toxicities in prepubertal male rats.

J Toxicol Environ Health A. 2018;81(11):421-431.

Ena L, Lim JS, Son JY, Park YJ, Lee YH, Kim JY, Kwack SJ, Lee BM, Ahn MY, Kim HS.

Molecular Insights into the Interaction of RONS and Thieno[3,2-c]pyran Analogs with SIRT6/COX-2: A Molecular Dynamics Study.

Sci Rep. 2018 Mar 19;8(1):4777.

Yadav DK, Kumar S, Saloni, Misra S, Yadav L, Teli M, Sharma P, Chaudhary S, Kumar N, Choi EH, Kim HS, Kim MH.

Identification of aldo-keto reductase (AKR7A1) and glutathione S-transferase pi (GSTP1) as novel renal damage biomarkers following
exposure to mercury.

Homan Exp. Toxicol., 2018. ;37(10):1025-1036.

Shin YJ, Kim KA, Kim ES, Kim JH, Kim HS, Ha M,
Bae ON.

DJ-1 controls bone homeostasis through the regulation of osteoclast differentiation. Nat. Commun., 18: 1519, 2017.	Kim HS, Nam ST, Mun SH, Lee SK, Kim HW, Park YH, Kim B, Won KJ, Kim HR, Park YM, Kim HS, Beaven MA, Kim YM, Choi WS.
Melatonin promotes osteoblast differentiation by regulating Osterix protein stability and expression. Sci. Report, 7: 5716, 2017.	Han Y, Kim YM, Kim HS, Lee KY.
Human microdosing and mice xenograft data of AGM‑130 applied to estimate efficacious doses in patients. Cancer Chemother Pharmacol. 28, 2017.	Park WS, Park GJ, Han S, Ban S, Park MY, Kim SH, Kim SM, Kim YC, Kim HS, Shin YC, Yim DS.
Synthesis and Anticancer Evaluation of 2,3-Disubstituted Indoles Derived from Azobenzenes and Internal Olefins. Eur. JOC, 6265-6273, 2017.	Oh Y, Han SH, Mishra NK, De U, Lee J, Kim HS, Jung YH, Kim IS.
Bromopropane compounds increase the stemness of colorectal cancer cells. Int. J. Mol. Sci., 2017	Cho YC, Nguyen TH, Park SY, Kim K, Kim HS, Kim H.
Development of Disposable Immunosensors for Rapid Determination of Sildenafil and Vardenafil in Functional Foods. J. Food Hyg. Saf. 32: 83-88, 2017.	Vijayaraj K, Lee JH, Kim HS, Chang SC.
Highly Eribulin-resistant KBV20C Oral Cancer Cells Can Be Sensitized by Co-treatment with the Third-generation P-Glycoprotein Inhibitor, Elacridar, at a Low Dose. Anticancer Res. 37(8): 4139-4146, 2017.	Park Y, Son JY, Lee BM, Yoon S, Kim HS.
Melatonin promotes osteoblast differentiation by regulating Osterix protein stability and expression. Sci. Rep., 18: 5716, 2017.	Han Y, Kim YM, Kim HS, Lee KY.
The JAK2 inhibitors CEP-33779 and NVP-BSK805 have high P-gp inhibitory activity and sensitize drug-resistant cancer cells to vincristine. Biochem. Biophys. Res. Commun. 490: 1176-1182, 2017	Cheon JH, Kim KS, Yadav DK, Kim M, Yoon S, Kim HS.
One-pot Synthesis of Oxindoles through C_H Alkylation and intramolecular cyclization of azobenzenes with internal olefins. ASC. 359: 1-7, 2017.	Han SH, Mishra NK, Jo H, Oh, Y, Jeon M, Kim S., Kim WJ, Lee JS, Kim HS, Kim IS.
Synthesis and anti-inflammatory evaluation of 2-aminobenzaldehydes via Ir(III)-catalyzed C-H amidation of aldimines with acyl azides. Journal of Organic Chemistry, 23: 223-248, 2017.	Kim S, Chakrasali P, Suh HS, Mishra NK, Kim T, Han SH, Kim HS, Lee BM, Kim IS.
Total Synthesis and Anti-inflammatory Evaluation of Penchinone A and Its Structural Analogues. Journal of Organic Chemistry, 82: 11566-11572, 2017.	Oh Y, Jang YJ, Jeon M, Kim HS, Kwak JH, Chung KH, Pyo S, Jung YH, Kim IS.
High dose tetrabromobisphenol A impairs hippocampal neurogenesis and memory retention. Food Chem. Toxicol., 106: 223-231, 2017.	Kim AH, Chun HJ, Lee S, Kim HS, Lee J.
Risk assessment of zinc oxide, a cosmetic ingredient used as a UV filter of sunscreens. J. Toxicol. Environ. Health, Part B.20:155-182, 2017.	Kim KB, Kim YW, Lim SK, Roh TH, Bang DY, Choi SM, Lim DS, Kim YJ, Baek SH, Kim MK, Seo HS, Kim MH, Kim HS, Lee JY, Kacew S, Lee BM.
Risk assessment of benzalkonium chloride in cosmetic products. J. Toxicol. Environ. Health, Part B.21:147-153, 2017.	Choi SM, Roh TH, Lim DS, Kacew S, Kim HS, Lee BM.
Synthesis and cytotoxic evaluation of N-aroylureas through rhodium(III)-catalyzed C_H functionalization of indolines with isocyanates. Adv. Synth Catal., 359: 1-9, 2017.	Jeong T, Lee SH, Mishra KN, De U, Park J, Dey P, Kwak JH, Jung YH, Kim HS, Kim IS.
Synthesis and anti-inflammatory evaluation of N-sulfonyl anthranilic acids via Ir(III)-catalyzed C–H amidation of benzoic acids. Bioorganic Med. Chem Lett., 27: 2129-2134, 2017.	Han SH, Suh HS, Jo H, Oh Y, Mishra NK, Han S, Kim HS, Jung YH, Lee BM, Kim IS.
Rhodium-catalyzed [3 + 2] annulation of cyclic N acyl ketimines with activated olefins: anticancer activity of spiroisoindolinones. Journal of Organic Chemistry, 82: 3359-3367, 2017.	Sharma S, Oh Y, Kumar NK, De U, Jo H, Sachan R, Kim HS, Jung YH, Kim IS.
Benzoic Acid Enhances Embryo Implantation through LIF-Dependent Expression of Integrin αVβ3 and αVβ5. J. Microbiol. Biotechnol., 27(4): 668-677, 2017.	Choi HJ, Chung TW, Park MJ, Kim HS, You S, Lee MS, Joo BS, Lee KS, Kim KJ, Wee G, Kim CY, Kim CH, Ha KT.
Identification of a sensitive urinary biomarker, selenium-binding protein 1, for early detection of acute kidney injury. J. Toxicol. Environ. Health Part A, 80(2): 363-369, 2017.	Kim KS, Yang HY, Song H, Kang YR, Kwon J, An J, Son JY, Kwack SJ, Kim YM, Bae ON, Ahn MY, Lee JW, Yoon S, Lee BM, Kim HS.
Selenium-binding protein 1: a sensitive urinary biomarker to detect heavy metal-induced nephrotoxicity. Arch. Toxicol. 91: 1635-1648, 2017.	Lee EK, Shin YJ, Park EY, Kim ND, Moon A, Kwack SJ, Son JY, Kacew S, Lee BM, Bae ON, Kim HS.
Activation of AMPK by berberine induces hepatic lipid accumulation by upregulation of fatty acid translocase CD36 in mice. Toxicol. Appl. Pharmacol., 316: 74-82, 2017.	Choi YJ, Lee KY, Jung SH, Kim HS, Shim G, Kim MG, Oh YK, Oh SH, Jun DW, Lee BH.
Site-Selective Rhodium(III)-Catalyzed C_H Amination of 7-Azaindoles with Anthranils: Synthesis and Anticancer Evaluation. ACS. 359: 3471-3478, 2017.	Jeon M, Park J, Dey P, Oh Y, Oh H, Han S, Um SH, Kim HS, Mishra NK, Kim IS.

Anticancer Effects of a New SIRT Inhibitor, MHY2256, against Human Breast Cancer MCF-7 Cells via Regulation of MDM2-p53 Binding. Int. J. Biol. Sci., 12(12):1555-1567, 2016.	Park EY, Woo Y, Kim SJ, Kim DH, Lee EK, De U, Kim KS, Lee J, Jung JH, Ha KT, Choi WS, Kim IS, Lee BM, Yoon S, Moon HR, Kim HS.
Genetic and epigenetic cancer chemoprevention on molecular targets during multistage carcinogenesis. Arch. Toxicol., 90(10):2389-404, 2016.	Kim HS, Kacew S, Lee BM.
Silica-coated magnetic nanoparticles impair proteasome activity and increase the formation of cytoplasmic inclusion bodies in vitro. Sci, Rep. 5;6:29095, 2016.	Phukan G, Shin TH, Shim JS, Paik MJ, Lee JK, Choi S, Kim YM, Kang SH, Kim HS, Kang Y, Lee SH, Mouradian MM, Lee G.
Cyclometallated iridium complexes inducing paraptotic cell death like natural products: synthesis, structure and mechanistic aspects. Dalton Trans. 45(38):15122-15136, 2016.	Tripathy SK, De U, Dehury N, Laha P, Panda MK, Kim HS, Patra S.
Rh(III)-Catalyzed C-H Functionalization of Indolines with Readily Accessible Amidating Reagent: Synthesis and Anticancer Evaluation. J. Org. Chem. 81(20):9878-9885, 2016.	Jeon M, Mishra NK, De U, Sharma S, Oh Y, Choi M, Jo H, Sachan R, Kim HS, Kim IS.
Co-treatment of LY294002 or MK-2206 with AZD5363 Attenuates AZD5363- induced Increase in the Level of Phosphorylated AKT. Anticancer Res. 36(11):5849-5858, 2016.	Choi AR, Kim JH, Woo YH, JH, Kim HS, Yoon S.
Co-treatment with Celecoxib or NS398 Strongly Sensitizes Resistant Cancer Cells to Antimitotic Drugs Independent of P-gp Inhibition. Anticancer Res. 36(10):5063-5070, 2016.	Lim JS, Park Y, Lee BM, Kim HS, Yoon S.
Highly Halaven-resistant KBV20C Cancer Cells Can Be Sensitized by Co-treatment with Fluphenazine. Anticancer Res. 36(11):5867-5874, 2016.	Cheon JH, Lee BM, Kim HS, Yoon S.
Attenuation of Colchicine Toxicity in Drug-resistant Cancer Cells by Co-treatment with Anti-malarial Drugs. Anticancer Res. 36(11):5859-5866, 2016.	Choi AR, Kim JH, Cheon JH, Kim HS, Yoon S.
Stable and biocompatible cystine knot peptides from the marine sponge Asteropus sp. Bioorg. Med. Chem., 24(13):2979-87, 2016.	Su M, Li H, Wang H, Kim EL, Kim HS, Kim EH, Lee J, Jung JH.
Anti-malarial Drugs Primaquine and Chloroquine Have Different Sensitization Effects with Anti-mitotic Drugs in Resistant Cancer Cells. Anticancer Res. 36(4):1641-8, 2016.	Choi AR, Kim JH, Woo YH, Kim HS, Yoon S.
Pyruvate Kinase M2: A Novel Biomarker for the Early Detection of Acute Kidney Injury. Toxicol. Res. 32(1):47-56, 2016.	Cheon JH, Kim SY, Son JY, Kang YR, An JH, Kwon JH, Song HS, Moon A, Lee BM, Kim HS.
Paeonia lactiflora Enhances the Adhesion of Trophoblast to the Endometrium via Induction of Leukemia Inhibitory Factor Expression. PLoS One. 11(2):e0148232, 2016.	Choi HJ, Chung TW, Park MJ, Lee KS, Yoon Y, Kim HS, Lee JH, Kwon SM, Lee SO, Kim KJ, Baek JH, Ha KT.
Mesenteric IL-10-producing CD5(+) regulatory B cells suppress cow's milk casein-induced allergic responses in mice. Sci. Rep. 6:19685, 2016.	Kim AR, Kim HS, Kim do K, Nam ST, Kim HW, Park YH, Lee D, Lee MB, Lee JH, Kim B, Beaven MA, Kim HS, Kim YM, Choi WS.
Integrin αVβ3 and αVβ5 are required for leukemia inhibitory factor-mediated the adhesion of trophoblast cells to the endometrial cells. Biochem .Biophys. Res. Commun. 469(4):936-40, 2016.	Chung TW, Park MJ, Kim HS, Choi HJ, Ha KT.
Discovery of urinary metabolomic biomarkers for early detection of acute kidney injury. Mol. Biosyst. 12(1):133-44, 2016.	Won AJ, Kim S, Kim YG, Kim KB, Choi WS, Kacew S, Kim KS, Jung JH, Lee BM, Kim S, Kim HS.
Toxicological evaluation of isopropylparaben and isobutylparaben mixture in Sprague-Dawley rats following 28 days of dermal exposure. Regul. Toxicol. Pharmacol. 73(2):544-51, 2016.	Kim MJ, Kwack SJ, Lim SK, Kim YJ, Roh TH, Choi SM, Kim HS, Lee BM.

5-Nitro-5'-hydroxy-indirubin-3'-oxime (AGM130), an indirubin-3'-oxime derivative, inhibits tumor growth by inducing apoptosis against non-small cell lung cancer in vitro and in vivo. Eur. J. Pharm. Sci. 79:122-31, 2015.	Ahn MY, Kim TH, Kwon SM, Yoon HE, Kim HS, Kim JI, Kim YC, Kang KW, Ahn SG, Yoon JH.
A New Histone Deacetylase Inhibitor, MHY219, Inhibits the Migration of Human Prostate Cancer Cells via HDAC1. Biomol. Ther. 23(5):434-41, 2015.	De U, Kundu S, Patra N, Ahn MY, Ahn JH, Son JY, Yoon JH, Moon HR, Lee BM, Kim HS.
Noninvasive biomarker candidates for cadmium-induced nephrotoxicity by 2DE/MALDI-TOF-MS and SILAC/LC-MS proteomic analyses. Toxicol. Sci. 148(1):167-82, 2015.	Kim SY, Lee HM, Kim KS, Kim HS, Moon A.
Mechanism of Cisplatin-Induced Cytotoxicity Is Correlated to Impaired Metabolism Due to Mitochondrial ROS Generation. PLoS One. 10(8):e0135083, 2015.	Choi YM, Kim HK, Shim W, Anwar MA, Kwon JW, Kwon HK, Kim HJ, Jeong H, Kim HM, Hwang D, Kim HS, Choi S.
Selenate specifically sensitizes drug-resistant cancer cells by increasing apoptosis via G2 phase cell cycle arrest without P-GP inhibition. Eur J Pharmacol. 5;764:63-9, 2015.	Choi AR, Jee Jo M, Jung MJ, Sik Kim H, Yoon S.
Anindoxylcompound5-bromo-4-chloro-3-indolyl1,3-diacetate,CAC-0982,suppressesactivationofFynkinaseinmastcellsandIgE-mediatedallergicresponsesinmice. Toxicol. Appl. Pharmacol. 285(3):179-186, 2015.	Lee JH, Kim TH, Kim HS,KimAR,Kim DK,Nam ST,KimHW,Park YH,HerE, ParkYM, KimHS, KimYM, ChoiWS.
Rhamnus davurica leaf extract inhibits Fyn activation by antigen in mast cells for anti-allergic activity. BMC Complement Altern. Med. 15:80, 2015.	Kim JH, Kim AR, Kim HS, Kim HW, Park YH, You JS, Park YM, Her E, Kim HS, Kim YM, Choi WS.
Phlda3, a urine-detectable protein, causes p53 accumulation in renal tubular cells injured by cisplatin. Cell Biol. Toxicol. 31(2):121-130, 2015.	Lee CG, Kang YJ, Kim HS, Moon A, Kim SG.
Interleukin-10-producing CD5+ B cells inhibit mast cells during immunoglobulin E-mediated allergic responses. Sci. Signal. 17;8(368), 2015.	Kim HS, Kim AR, Kim do K, Kim HW, Park YH, Jang GH, Kim B, Park YM, You JS, Kim HS, Beaven MA, Kim YM, Choi WS.
Protective Effects of Quercetin Against HgCl2-InducedNephrotoxicityinSprague-DawleyRats. J .Med. Food, 18(5):524-34, 2015.	Shin YJ, Kim JJ, Kim YJ, Kim WH, Park EY, Kim IY, Shin HS, Kim KS, Lee EK, Chung KH, Lee BM, Kim HS.
Apicidin inhibits cell growth by downregulating IGF-1R in salivary mucoepidermoid carcinoma cells. Oncol. Rep. 33(4):1899-907, 2015.	Ahn MY, Ahn JW, Kim HS, Lee J, Yoon JH.
Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts. Biochim. Biophys. Acta. 1850(2):401-410, 2015.	Kim TH, Kim HS, Kang YJ, Yoon S, Lee J, Choi WS, Jung JH, Kim HS.

Risk assessment of volatile organic compounds benzene, toluene, ethylbenzene, and xylene (BTEX) in consumer products.

J. Toxicol. Environ. Health A. 2014;77(22-24):1502-21.

Lim SK, Shin HS, Yoon KS, Kwack SJ, Um YM,

Hyeon JH, Kwak HM, Kim JY, Kim TY, Kim YJ, Roh TH, Lim DS, Shin MK, Choi SM, Kim HS, Lee BM.

Evaluation of cadmium-induced nephrotoxicity using urinary metabolomic profiling in Sprague-Dawley rats.

J. Toxicol. Environ. Health. 2014;77(22-24):1384-98.

Lee YK, Park EY, Kim S, Son JY, Kim TH, Kang WG, Jeong TC, Kim KB, Kwack SJ, Lee J, Kim S, Lee BM, Kim HS,

Comparative efficacy and bioequivalence of novel h1-antihistamine bepotastine salts (nicotinate and salicylate).

J. Toxicol. Environ. Health A. 2014;77(22-24):1451-66.

Lim DS, Youn YS, Kwack SJ, Kwak HM, Lim SK,
Kim JY, Um YM, Lee JD, Hyeon JH, Kim YJ, Kim HS, Lee BM.

Potential application of benzo(a)pyrene-associated adducts (Globin or lipid) as blood biomarkers for target organ exposure and
human risk assessment.

J. Toxicol. Environ. Health. 2014;77(22-24):1491-501.

Kwack SJ, Kim DY, Kim YJ, Roh TH, Choi SM, Lim DS, Shin HS, Kim HS, Lee BM.

A one-generation reproductive toxicity study of 3,4-methylenedioxy-n-methamphetamine (MDMA, Ecstasy), an amphetamine derivative,
in C57BL/6 mice.

J. Toxicol. Environ. Health A. 2014;77(22-24):1431-42.

Kwack SJ, Yoon KS, Lim SK, Gwak HM, Kim JY,
Um YM, Lee JD, Hyeon JH, Kim YJ, Kim HS, Lee BM.

Nephrotoxic potential and toxicokinetics of melamine combined with cyanuric acid in rats.

J. Toxicol. Environ. Health. 2014;77(22-24):1346-58.

Kim GH, Kang MJ, Noh K, Oh DG, Kang WK,
Jeong HG, Lee KY, Kim H, Kim HS, Jeong TC.

Viriditoxin regulates apoptosis and autophagy via mitotic catastrophe and microtubule formation in human prostate cancer cells.

Int. J. Oncol. 2014 Dec;45(6):2331-40.

Kundu S, Kim TH, Yoon JH, Shin HS, Lee J, Jung JH, Kim HS.

Ru(II)-catalyzed selective C-H amination of xanthones and chromones with sulfonyl azides: synthesis and anticancer evaluation.

J. Org. Chem. 2014 Oct 3;79(19):9262-71.

Shin Y, Han S, De U, Park J, Sharma S, Mishra NK,
Lee EK, Lee Y, Kim HS, Kim IS.

Dinuclear [{(p-cym)RuCl}2(μ-phpy)](PF6)2 and heterodinuclear [(ppy)2Ir(μ-phpy)Ru (p-cym)Cl] (PF6)2 complexes: synthesis,
structure and anticancer activity.

Dalton Trans. 2014 Oct 21;43(39):14546-9.

Tripathy SK, De U, Dehury N, Pal S, Kim HS, Patra S.

α-Linolenic acid: nutraceutical, pharmacological and toxicological evaluation.

Food Chem. Toxicol. 2014 Aug;70:163-78.

Kim KB, Nam YA, Kim HS, Hayes AW, Lee BM.

Identification of Noninvasive Biomarkers for Nephrotoxicity UsingHK-2HumanKidneyEpithelialCells.

Toxicol. Sci., 2014, Jun;30(2):99-107.

Kim SY, Kim HS, Moon A.

Age-related differences in kidney injury biomarkers induced by cisplatin.

Environ. Toxicol. Pharmacol. 2014 Mar 26;37(3):1028-1039.

Shin YJ, Kim TH, Won AJ, Jung JY, Kwack SJ,
Kacew S, Chung KH, Lee BM, Kim HS.

Estrogenic endocrine-disrupting chemicals: molecular mechanisms of actions on putative human diseases.

J. Toxicol. Environ. Health B Crit Rev. 2014;17(3):127-74.

Yoon K, Kwack SJ, Kim HS, Lee BM.

Synthesis of PPAR-γ activators inspired by the marine natural product, paecilocin A.

Mar. Drugs. 2014 Feb 13;12(2):926-39.

Xiao B, Su M, Kim EL, Hong J, Chung HY, Kim HS,
Yin J, Jung JH.

Solution structure of a sponge-derived cystine knot peptide and its notable stability.

J. Nat. Prod. 2014 Feb 28;77(2):304-10.

Li H, Su M, Hamann MT, Bowling JJ, Kim HS,
Jung JH.

A novel oxiranylchromenone derivative, MHY336, induces apoptosis and cell cycle arrest via a p53- and p21-dependent pathway in
HCT116 human colon cancer cells.

Int. J. Oncol. 2014 Mar;44(3):943-9.

Lee SH, Kang YJ, Kim DH, Sung B, Kang JA, Chun P, Yoon JH, Moon HR, Kim HS, Chung HY, Kim ND.

SP600125 overcomes antimitotic drug-resistance in cancer cells by increasing apoptosis with independence of P-gp inhibition.

Eur J Pharmacol. 2014;723:141-7.

Kim JH, Chae M, Choi AR, Kim HS, Yoon S.

A novel hydroxamic acid derivative, MHY218, induces apoptosis and cell cycle arrest through downregulation of NF-κB in HCT116 human
colon cancer cells.

Int. J. Oncol. 2014;44(1):256-64.

Kim MK, Kang YJ, Kim DH, Hossain MA, Jang JY,
Lee SH, Yoon JH, Chun P, Moon HR, Kim HS,
Chung HY, Kim ND.

Resveratrol enhances chemosensitivity of doxorubicin in multidrug-resistant human breast cancer cells via increased cellular influx of doxorubicin.

Biochim. Biophys. Acta. 2014;1840(1):615-625.

Kim TH, Shin YJ, Won AJ, Lee BM, Choi WS, Jung JH, Chung HY, Kim HS.

A novel anthracene derivative, MHY412, induces apoptosis in doxorubicin-resistant human breast cancer MCF-7/Adr cells through cell cycle arrest and down-regulation of p-glycoprotein expression.

Int. J. Oncol. 2014;44(1):167-176.

De U, Chun P, Choi WS, Lee BM, Moon HR, Kim HS.

Low Amount of Salinomycin Greatly Increases Akt Activation, but Reduces Activated p70S6K Levels. Int. J. Mol. Sci. 2013;14(9):17304-18.	Kim JH, Choi AR, Kim YK, Kim HS, Yoon S.
Low Amount of Salinomycin Greatly Increases Akt Activation, but Reduces Activated p70S6K Levels. Int. J. Mol. Sci. 2013;14(9):17304-18.	Kim JH, Choi AR, Kim YK, Kim HS, Yoon S.
Triclosan exhibits a tendency to accumulate in the epididymis and shows sperm toxicity in male sprague-dawley rats. Environ Toxicol. 2013 Aug 9. [Epub ahead of print]	Lan Z, Hyung Kim T, Shun Bi K, Hui Chen X, Kim HS.
A novel histone deacetylase (HDAC) inhibitor MHY219 induces apoptosis via up-regulation of androgen receptor expression in human prostate cancer cells. Biomed Pharmacother. 2013 Jun;67(5):407-15.	Patra N, De U, Kim TH, Lee YJ, Ahn MY, Kim ND, Yoon JH, Choi WS, Moon HR, Lee BM, Kim HS.
Baicalein, an active component of Scutellaria baicalensis Georgi, induces apoptosis in human colon cancer cells and prevents AOM/DSS-induced colon cancer in mice. Int J Oncol. 2013;43(5):1652-8.	Kim DH, Hossain MA, Kang YJ, Jang JY, Lee YJ, Im E, Yoon JH, Kim HS, Chung HY, Kim ND.
Uterotrophic and Hershberger Assays for Endocrine Disruption Properties of Plastic Food Contact Materials Polypropylene (PP) and Polyethylene Terephthalate (PET). J Toxicol Environ Health A. 2013;76(10):624-34.	Chung BY, Kyung M, Lim SK, Choi SM, Lim DS, Kwack SJ, Kim HS, Lee BM.
Potential metabolomic biomarkers for evaluation of adriamycin efficacy using a urinary (1) H-NMR spectroscopy. J. Appl. Toxicol. 2013 Jul 11. doi: 10.1002/jat.2778. [Epub ahead of print].	Kim KB, Yang JY, Kwack SJ, Kim HS, Ryu DH, Kim YJ, Bae JY, Lim DS, Choi SM, Kwon MJ, Bang DY, Lim SK, Kim YW, Hwang GS, Lee BM.
A novel histone deacetylase (HDAC) inhibitor MHY219 induces apoptosis via up-regulation of androgen receptor expression in human prostate cancer cells. Biomed Pharmacother. 2013;67(5):407-15.	Patra N, De U, Kim TH, Lee YJ, Ahn MY, Kim ND, Yoon JH, Choi WS, Moon HR, Lee BM, Kim HS.
Safety evaluation and risk assessment of d-Limonene. J. Toxicol. Environ. Health B Crit Rev. 2013;16(1):17-38.	Kim YW, Kim MJ, Chung BY, Bang du Y, Lim SK, Choi SM, Lim DS, Cho MC, Yoon K, Kim HS, Kim KB, Kim YS, Kwack SJ, Lee BM.
Development and application of risk management system for consumer products in compliance with global harmonization. J. Toxicol. Environ. Health B Crit Rev. 2013;16(1):1-16.	Song JB, Ahn IY, Cho KT, Kim YJ, Kim HS, Lee BM.
Correction to PPAR-γ Agonistic Metabolites from the Ascidian Herdmania momus. J. Nat. Prod. 2013 Apr 9. [Epub ahead of print]	Li JL, Xiao B, Park M, Yoo ES, Shin S, Hong J, Chung HY, Kim HS, Jung JH.
Selective impairment on the proliferation of neural progenitor cells by oxidative phosphorylation disruption. Neurosci. Lett. 2013;535:134-9.	Lee Y, Oh SB, Park HR, Kim HS, Kim MS, Lee J.
Morus bombycis extract suppresses mast cell activation and IgE-mediated allergic reaction in mice. J Ethnopharmacol. 2013;146(1):287-93.	Kim JD, Kim do K, Kim HS, Kim AR, Kim B, Her E, Park KH, Kim HS, Kim YM, Choi WS.
In vitro evaluation of biomarkers for cisplatin-induced nephrotoxicity using HK-2 human kidney epithelial cells. Toxicol Lett. 2013;217(3):235-42.	Sohn SJ, Kim SY, Kim HS, Chun YJ, Han SY, Kim SH, Moon A.
DJ-1 regulates mast cell activation and IgE-mediated allergic responses. J. Allergy Clin,. Immunol., 2013;131(6):1653-62.	Kim DK, Kim HS, Kim AR, Kim JH, Kim B, Noh G, Kim HS, Beaven MA, Kim YM, Choi WS.
Triclosan exhibits a tendency to accumulate in the epididymis and shows sperm toxicity in male sprague-dawley rats. Environ. Toxicol. 2013 Aug 9. [Epub ahead of print]	Lan Z, Kim TH, Shun BK, Hui CX, Kim HS.
Uterotrophic and Hershberger Assays for Endocrine Disruption Properties of Plastic Food Contact Materials Polypropylene (PP) and Polyethylene Terephthalate (PET). J Toxicol Environ Health A. 2013 May;76(10):624-34.	Chung BY, Kyung M, Lim SK, Choi SM, Lim DS, Kwack SJ, Kim HS, Lee BM.
Diallyl disulfide impairs hippocampal neurogenesis in the young adult brain. Toxicol. Lett. 2013, 221(1):31-38.	Ji ST, Kim MS, Park HR, Lee E, Lee Y, Jang YJ, Kim HS, Lee J.
Correction to PPAR-γ Agonistic Metabolites from the Ascidian Herdmania momus. J. Nat. Prod. 2013 Apr 9. [Epub ahead of print]	Li JL, Xiao B, Park M, Yoo ES, Shin S, Hong J, Chung HY, Kim HS, Jung JH.
Selective impairment on the proliferation of neural progenitor cells by oxidative phosphorylation disruption. Neurosci Lett. 2013, 535:134-9.	Lee Y, Oh SB, Park HR, Kim HS, Kim MS, Lee J.

Molecular Mechanism of SAHA on Regulation of Autophagic Cell Death in Tamoxifen-Resistant MCF-7 Breast Cancer Cells. Int. J. Med. Sci. 2012; 9(10):881-93.	Lee YJ, Won AJ, Lee J, Jung JH, Yoon S, Lee BM, Kim HS.
Concentration Increases Apoptotic Detachment in High-Density Cancer Cells. Int. J. Mol. Sci. 2012, 13, 13169-13182.	Kim JH, Tae Young Kim TY, Kim HS, Hong S and Yoon S. Lower Salinomycin
Novel dihydrobenzofuro[4,5-b][1,8]naphthyridin-6-one derivative, MHY-449, induces apoptosis and cell cycle arrest in HCT116 human colon cancer cells. Int. J. Oncol. 2012,41(6):2057-64	Hwang HJ, Kang YJ, Hossain MA, Kim DH, Jang JY, Lee SH, Yoon JH, Moon HR, Kim HS, Chung HY, Kim ND.
A novel carbazole derivative, MHY407, sensitizes breast cancer cells to doxorubicin-, etoposide-, and radiation-treatment via DNA damage and cell cycle arrest. Eur. J. Pharmacol. 2012, 697(1-3):24-31	Yoon S, Kim JH, Lee YJ, Choi G, Yang Z, Lee HJ, Moon HR, Kim HS.
Apicidin inhibits human ovarian cancer cells migration and invasion through class II histone deacetylase (HDAC) 4 silencing. Cancer Letters, 2012; 325(2):189-99.	Ahn MY, Na YJ, Lee J, Jeung HY, Kim HS.
Human Risk Assessment of Endocrine-Disrupting Chemicals Derived from Plastic Food Containers. CRFSFS. 2012, 11; 453-470.	Bang DY, Kyung M, Kim MJ, Jung BY, Cho MC, Choi SM, Kim YW, Lim SG, Lim DS, Won AJ, Kwack SJ, Lee YK, Kim HS, Lee BM.
Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells. Int. J. Oncol. 2012; 41(3):1101-1109.	Wang J, Kim TH, Ahn MY, Lee J, Jung JH, Choi WS, Lee BM, Yoon KS, Yoon S, Kim HS.
Evaluation of metabolomic profiling against renal toxicity in Sprague-Dawley rats treated with melamine and cyanuric acid. Arch. Toxicol., 2012, 86:1885-1897.	Kim TH, Lim HJ, Lee YJ, Shin YJ, Ahn MY, De U, Lee JW, Lee BM, Kim S, Kim HS.
In vitro stability and in vivo anti-inflammatory efficacy of synthetic jasmonates. Bioorg. Med. Chem. 2012; 20(13):4109-16.	Dang HT, Lee YM, Kang GJ, Yoo ES, Hong J, Lee SM, Lee SK, Pyee Y, Chung HJ, Moon HR, Kim HS, Jung JH.
High dose bisphenol A impairs hippocampal neurogenesis in female mice across generations. Toxicology. 2012; 296(1-3):73-82.	Jang YJ, Park HR, Kim TH, Yang WJ, Lee JJ, Choi SY, Oh SB, Lee E, Park JH, Kim HP, Kim HS, Lee J.
Evaluation of in vitro screening system for estrogenicity: comparison of stably transfected human estrogen receptor-α transcriptional activation (OECD TG455) assay and estrogen receptor (ER) binding assay. J. Toxicol. Sci. 2012; 37(2):431-437.	Lee HK, Kim TS, Kim CY, Kang IH, Kim MG, Kyung Jung K, Kim HS, Han SY, Yoon HJ, Rhee GS.
JNK activation by upregulation of iNOS upon cholesterol accumulation limits neurogenesis and induces region specific DNA damage responses in the SVZ of NPC mice. J. Pharm. Pharmacol. 2012; 64(3):420-429.	Kim HS, Kim AR, Lee JM, Kim SN, Choi JH, Kim do K, Kim JH, Kim B, Her E, Yang YM, Kim HS, Kim YM, Choi WS.
Comparisons of polybrominated diphenyl ethers levels in paired South Korean cord blood, maternal blood, and breast milk samples. Chemosphere. 2012; 87(1):97-104.	Kim TH, Bang du Y, Lim HJ, Won AJ, Ahn MY, Patra N, Chung KK, Kwack SJ, Park KL, Han SY, Choi WS, Han JY, Lee BM, Oh JE, Yoon JH, Lee J, Kim HS.
Chemopreventive mechanisms of methionine on inhibition of benzo(a)pyrene-DNA adducts formation in human hepatocellular carcinoma HepG2 cells. Toxicol. Lett. 2012; 208(3):232-238.	Roh T, Kwak MY, Kwak EH, Kim DH, Han EY, Bae JY, Bang du Y, Lim DS, Ahn IY, Jang DE, Lim SK, Yoo SD, Kwack SJ, Park KL, Lee YJ, Kim KB, Lee J, Kim HS, Lee BM.
The hepatoprotective effects of adenine nucleotide translocator-2 against aging and oxidative stress. Free Radic. Res. 2012; 46(1):21-9	Kim HS, Je JH, Son TG, Park HR, Ji ST, Pokharel YR, Jeon HM, Kang KW, Kang HS, Chang SC, Kim HS, Chung HY, Lee J.
A new synthetic HDAC inhibitor, MHY218, induces apoptosis or autophagy-related cell death in tamoxifen-resistant MCF-7 breast cancer cells. Invest New Drugs. 2012; 30:1887-1898.	Park JH, Ahn MY, Kim TH, Yoon S, Kang KW, Lee J, Moon HR, Jung JH, Chung HY, Kim HS.

Organic solvent metabolite, 1,2-diacetylbenzene, impairs neural progenitor cells and hippocampal neurogenesis. Chem. Biol. Interact. 2011; 194(2-3):139-47.	Kim MS, Park HR, Chung HY, Kim HS, Yu BP, Yang HS, Lee J.
Exposure to bisphenol A appears to impair hippocampal neurogenesis and spatial learning and memory. Food Chem Toxicol. 2011; 49(12):3383-9.	Kim ME, Park HR, Gong EJ, Choi SY, Kim HS, Lee J.
4-Chlorotetrazolo[1,5-a]quinoxaline inhibits activation of Syk kinase to suppress mast cells in vitro and mast cell-mediated passive cutaneous anaphylaxis in mice. Toxicol Appl Pharmacol. 2011; 257(2):235-41.	Park KL, Ko NY, Lee JH, Kim do K, Kim HS, Kim AR, Her E, Kim B, Kim HS, Moon EY, Kim YM, Kim HR, Choi WS.
Monitoring of PBDEs concentration in umbilical cord blood and breast milk from Korean population and estimating the effects of various parameters on accumulation in humans. Chemosphere. 2011; 85(3):487-93	Kim UJ, Lee IS, Kim HS, Oh JE.
Design, synthesis and anticancer activity of novel dihydrobenzofuro[4,5-b][1,8]naphthyridin-6-one derivatives. Bioorg. Med. Chem. Lett. 2011; 21(19):5730-4	Kang JA, Yang Z, Lee JY, De U, Kim TH, Park JY, Lee HJ, Park YJ, Chun P, Kim HS, Jeong LS, Moon HR.
Antibacterial polyketides from the jellyfish-derived fungus Paecilomyces variotii. J. Nat. Prod. 2011;74(8):1826-9.	Liu J, Li F, Kim EL, Li JL, Hong J, Bae KS, Chung HY, Kim HS, Jung JH.
A novel epoxypropoxy flavonol derivative topoisomerase II inhibitor, MHY336, induces apoptosis in prostate cancer cells. Eur. J. Pharmacol, 2011; 658(2-3):98-107.	Patra N, De U, Kang J-A, Kim JM, Ahn MY, Moon HR, Jung JH, Chung HY, Kim HS.
Evaluation of endogenous fatty acid amides and their synthetic analogues as potential anti-inflammatory leads. Bioorg Med Chem. 2011; 19(4):1520-7.	Dang HT, Kang GJ, Yoo ES, Hong J, Choi JS, Kim HS, Chung HY, Jung JH.
Role of PTEN promoter methylation in tamoxifen-resistant breast cancer cells. Breast Cancer Res. Treat. 2011; 130(1):73-83.	Phuong NT, Kim SK, Lim SC, Kim HS, Kim TH, Lee KY, Ahn SG, Yoon JH, Kang KW.
Role of phospholipase D in regulation of testicular Leydig cell hyperplasia in Sprague-Dawley rats treated with di(2-ethylhexyl) phthalate. Arch. Toxicol. 2011; 85(8):975-85.	Lee YJ, Ahn MY, Kwack SJ, Park KL, Yoon S, Min D. Kim HS.
Salinomycin sensitizes cancer cells to the effects of doxorubicin and etoposide treatment by increasing DNA damage and reducing p21 protein. Br. J. Pharmacol. 2011; 162(3):773-84.	Kim JH, Chae M, Kim WK, Kim YJ, Kang HS, Kim HS, Yoon S.
Autoregulation of phospholipase D activity is coupled to selective induction of phospholipase D1 expression to promote in vasion of breast cancer cells. Int. J. Cancer. 2011; 128(4):805-16.	Kang DW, Park MH, Lee YJ, Kim HS, Lindsley CW, Brown HA, Min DS.
Interleukin-32 production is regulated by MyD88-dependent and independent pathways in IL-1-stimulated human alveolar epithelial cells. Immunobiology 2011, 216(1-2):32-40.	Ko NY, Mun SM, Kim JW; Kim DK, Kim HS, Her S, Kim HS, Shin HS, Kim YM, Choi WS.

Amurensin G, a potent natural SIRT1 inhibitor, rescues doxorubicin responsiveness via down-regulation of multidrug resistance 1. Mol Pharmacol. 2010; 78(5):855-64.	Oh WK, Cho KB, Hien TT, Kim TH, Kim HS, Dao TT, Han HK, Kwon SM, Ahn SG, Yoon JH, Kim TH, Kim YG, Kang KW.
A rapid method to determine tetrabromobisphenol a in rat serum and urine by liquid chromatography-tandem mass spectrometry. Arch Pharm Res. 2010; 33(11):1797-803.	Kang MJ, Kim JH, Lee SK, Kang W, Kim HS, Lyoo WS, Jeong TC.
Ginsenoside Rg3 inhibits tumor necrosis factor-alpha-induced expression of cell adhesion molecules in human endothelial cells. Pharmazie. 2010; 65(9):699-701.	Hien TT, Kim ND, Kim HS, Kang KW.
Functional role of phospholipase D (PLD) in di(2-ethylhexyl) phthalate-induced hepatotoxicity in Sprague-Dawley rats. J Toxicol Environ Health A. 2010; 73(21-22):1560-9.	Kim NY, Kim TH, Lee E, Patra N, Lee J, Shin MO, Kwack SJ, Park KL, Han SY, Kang TS, Kim SH, Lee BM, Kim HS.
Effects of in utero exposure to DI(n-Butyl) phthalate on development of male reproductive tracts in Sprague-Dawley rats. J Toxicol Environ Health A. 2010; 73(21-22):1544-59.	Kim TS, Jung KK, Kim SS, Kang IH, Baek JH, Nam HS, Hong SK, Lee BM, Hong JT, Oh KW, Kim HS, Han SY, Kang TS.
Capsaicin impairs proliferation of neural progenitor cells and hippocampal neurogenesis in young mice. J Toxicol Environ Health A. 2010; 73(21-22):1490-501.	Kong KH, Kim HK, Song KS, Woo YS, Choi WS, Park HR, Park M, Kim ME, Kim MS, Ryu JS, Kim HS, Lee J.
Toxicometabolomics of urinary biomarkers for human gastric cancer in a mouse model. J Toxicol Environ Health A. 2010 Jan;73(21-22):1420-30.	Kim KB, Yang JY, Kwack SJ, Park KL, Kim HS, Ryu do H, Kim YJ, Hwang GS, Lee BM.
Comparative nephrotoxicitiy induced by melamine, cyanuric acid, or a mixture of both chemicals in either Sprague-Dawley rats or renal cell lines. J Toxicol Environ Health A. 2010 Jan;73(21-22):1407-19.	Choi L, Kwak MY, Kwak EH, Kim DH, Han EY, Roh T, Bae JY, Ahn IY, Jung JY, Kwon MJ, Jang DE, Lim SK, Kwack SJ, Han SY, Kang TS, Kim SH, Kim HS, Lee BM.
Evaluation of liver and thyroid toxicity in Sprague-Dawley rats after exposure to polybrominated diphenyl ether BDE-209. J Toxicol Sci. 2010;35(4):535-45.	Lee E, Kim TH, Choi JS, Nabanata P, Kim NY, Ahn MY, Jung KK, Kang IH, Kim TS, Kwack SJ, Park KL, Kim SH, Kang TS, Lee J, Lee BM, Kim HS.
Anticancer effects of the MHY218 novel hydroxamic acid-derived histone deacetylase inhibitor in human ovarian cancer cells. Int J Oncol. 2010 Aug;37(2):419-28.	Jeon HS, Ahn MY, Park JH, Kim TH, Chun P, Kim WH, Kim J, Moon HR, Jung JH, Kim HS.
Enhanced effect of losartan and rosuvastatin on neointima hyperplasia. Arch. Pharm. Res. 2010 Apr;33(4):593-600. Epub 2010 Apr 27.	Yi I, Lee JJ, Park JS, Zhang WY, Kim IS, Kim Y, Shin CY, Kim HS, Myung CS.
In vitro study of endocrine disruptor screening and testing methods-establishment of a recombinant rat androgen receptor binding assay. J. Toxicol. Sci., 2010;35(2): 239-43.	Heo HS, Oh SJ, Kim JM, Kim HS, Chung HY.
Comparison of the short term toxicity of phthalate diesters and monoesters in Sprague-Dawley rats. Toxicological Research 26(1) 75-82, 2010.	Kwack SJ, Han EY, Park JS, Bae JY, Ahn IY, Lim SK, Kim DH, Jang DE, Choi L, Lim HJ, Kim TH, Patra N, Kim HS, Lee BM.
Acrylamideinducesapoptosisinneuralprogenitorcellsandimpairshippocampalneurogenesis. Toxicology Letters, 193(1) 86-93, 2010.	Park HR, Kim MS, Kim SJ, Park MK, Kong KH, Kwack SJ, Kang TS, Kim SH, KimHS,LeeJ.
Anti-tumor effect of apicidin on Ishikawa human endometrial cancer cells both in vitro and in vivo by blocking histone deacetylase 3 and 4. International J. Oncology, 36: 125-131, 2010.	Ahn MY, Jung HY, Choi WS, Lee BM, Lee J, Yoon S, KimHS.

Jnk signaling pathway-mediated regulation of Stat3 activation is linked to the development of doxorubicin resistance in cancer cell lines. Biochem. Pharmacol. 2009 Sep 18.	Kim JH, Lee SC, Ro J, Kang HS, Kim HS, Yoon S.
Design, synthesis, antitumor activity and mode of action of novel oxiranyl and thiiranyphenol derivatives. Bull. Korean Chem. Soc., 30(7): 1463-1469, 2009.	Yang Z, Kang JA, Kim WH, Park AY, Kim HS, Kim J, Kim JA, Jeong LS, Moon HR.
SP600125, aninhibitor of Jnk pathway, reduces viability of relatively resistant cancer cells to doxorubicin. Biochemical and Biophysical Research Communications, 387(3):450-455, 2009.	Kim JH, Kim TH, Kang HS, Ro J, Kim HS, Yoon S.
Exposure assessment of polybrominated diphenyl ethers in umbilical cord blood of Korean infants. Journal of Toxicology and Environmental Health A, 72, 1318-1326, 2009.	Kim TH, Lee YJ, Lee E, Patra N, Lee J, Kwack SJ, Kim KB, Chung KK, Han SY, Han JY, Lee BM, Kim HS.
Effects of gestational exposure to decabromodiphenyl ether on reproductive parameters, thyroid hormone levels, and neuronal development in Sprague-Dawley rat offspring. Journal of Toxicology and Environmental Health A, 72, 1296-1303, 2009	Kim TH, Lee YJ, Lee E, Kim MS, Kwack SJ, Kim KB, Chung KK, Kang TS, Han SY, Lee JW, Lee BM, KimHS.
Risk assessment of tetrabromobisphenol A on cyclooxygenase-2 expression via MAP Kinase/NF-κB/ AP-1 signaling pathways in murine macrophages. Journal of Toxicology and Environmental Health A, 72: 1431-1438, 2009.	Han EH, Park JH, Kang KW, Jeong TC, Kim HS, Jeong HG.
Risk assessment of soybean-based phytoestrogens. Journal of Toxicology and Environmental Health A, 72:1254-1261, 2009.	Kwack SJ, Kim KB, Kim HS, Lee BM.
Risk assessment of bisphenol A migration from canned food in korea. Journal of Toxicology and Environmental Health A, 72:1327-1335, 2009	Lim DS, Kwack SJ, Kim KB, Kim HS, Lee B.
Potential risk of bisphenol A migration from polycarbonate container safter heating, boiling and microwaving. Journal of Toxicology and Environmental Health A, 72: 1285-1291, 2009.	Lim DS, Kwack SJ, Kim KB, Kim HS, Lee BM.
Comparative toxicological evaluation of phthalate diesters and metabolites in Sprague-Dawley male rats for risk assessment. Journal of Toxicology and Environmental Health A, 72: 1446-1454, 2009.	Kwack SJ, Kim KB, Kim HS, Lee BM.
Risk assessment for the combinational effects of food color additive: Neuralprogenitorcellsandhippocampalneurogenesis. Journal of Toxicology and Environmental Health A, 72: 1412-1423, 2009.	Park HR, Park M, Kim SJ, Kwon M, Yu BP, Chung HY, Kim HS, Kwack SJ, Kang TS, Kim SH, Lee J.
Potencies of bisphenol A on the neuronal differentiation and hippocampal neurogenesis. Journal of Toxicology and Environmental Health A, 72: 1285-1291, 2009.	Park HR, Park M, Kim SJ, Kwon M, Yu BP, Chung HY, Kim HS, Kwack SJ, Kang TS, Kim SH, Lee J.
Nephrotoxic potential and toxicokinetics of tetrabromobisphenol A in rat for risk assessment. Journal of Toxicology and Environmental Health A, 72; 1429-1445, 2009.	Kang MJ, Kim JH, Shin S, Choi JH, Lee SK, Kim HS, Kim ND, Kang GW, Jeong HG, Kang W and Jeong TC.
Neurotoxic effect of 2,5-hexanedione on neural progenitor cells and hippocampal neurogenesis. Toxicology, 260(1-3):97-103, 2009.	Kim MS, Park HR, Park M, Kim SJ, Kwon M, Yu BP, Chung HY, Kim HS, Kwack SJ, Kang TS, KimSH,LeeJ.
2-Deoxy-d-glucose protects neural progenitor cells against oxidative stress through the activation of AMP-activated protein kinase. Neurosci Lett. 449(3):201-206, 2009.	Park M, Song KS, Kim HK, Park YJ, KimHS,BaeMI,LeeJ.
Morin inhibits Fyn kinase in mast cells and IgE-mediated type I hypersensitivity response in vivo. Biochem. Pharmacol., 77(9):1506-1512, 2009.	Kim JW, Lee JH, Hwang BY, Mun SH, Ko NY, Kim do K, Kim B, Kim HS, Kim YM, Choi WS.
Tumor necrosis factor alpha-induced interleukin-32 is positively regulated via the Syk/protein kinase Cdelta/JNK pathway in rheumatoid synovial fibroblasts. Arthritis Rheum. 60(3):678-685, 2009.	Mun SH, Kim JW, Nah SS, Ko NY, Lee JH, Kim JD, Kim do K, Kim HS, Choi JD, Kim SH, Lee CK, Park SH, Kim BK,Kim HS,Kim YM, Choi WS.
Mechanism of apicidin-induced cell cycle arrest and apoptosis in Ishikawa human endometrial cancer cells. Chemico-Biological Interactions, 179(2) 169-177, 2009.	Ahn MY, Na YJ, Kwang KW, Choi WS, Lee BM, Lee J, Kim HS.
Apicidin induces apoptosis via cytochromec- mediated intrinc pathway in human ovarian cancer cells. Biomolecules & Therapeutics. 17(1)17-24, 2009.	Ahn MY, Na YJ, Lee J, Kim HS.
Effects of Di(2-ethylhexyl) Phthalate on Regulation of Steroidogenesis or Spermatogenesis in Testes of Sprague-Dawley Rats. Journal of Health Science. 55(3) 380-388, 2009.	Lee YJ, Lee E, Kim TH, Choi JS, Lee J, Jung KK, Kwack SJ, Han SY, Lee BM and KimHS.

Differential effects of histone deacetylase inhibitors on cell cycle regulation and apoptosis in human prostate cancer cells. Journal of Theoretical and Experimental Pharmacology, 1(1) 142-158, 2008.	Kim HJ, Han JY, Kim HS.
Molecular mechanism of dietary restriction in neuroprevention and neurogenesis: Involvement of neurotrophic factors. Toxicological Research, 24(4) 245-251, 2008.	Park HR, Park MK, Kim HS, Lee J.
Molecular mechanism of progesterone-induced apoptosis in human breast cancer T47D cells. Cancer Prevention Research, 13(3) 177-183, 2008.	Kim TH, Im JY, Lee BM, Kim IY, Kim HS.
Effects of Trichostatin A, a histone deacetylase inhibitor, on the regulation of apoptosis in H-ras-transformed breast epithelial cells. International Journal of Molecular Medicine. 22(5) 605-611, 2008.	Park HY, Lee YJ, Kim TH, Lee J, Yoon S, Choi WS, Myung CS, Kim HS.
Time-response effects of testicular genes expression profiles in Sprague-Dawley rats treated withdi(n-butyl)phthalate. Journal of Toxicology & Environmental Health, 71(23) 1542-1549, 2008.	Ryu JY, Lee E, Kim TH, Lee YJ, Lee J, Lee BM, Kwack SJ, Jung KK, Han SY, Kim SH, Kim HS.
Mast cell-mediated allergic response is suppressed by Sophorae Flos: Inhibition of Src-family kinase. Experimental Biology and Medicine, 233(10) 1271-1279, 2008.	Lee JH, Kim JW, Ko NY, Mun SH, Kim DK, Kim JD, Won HS, Shin HS, Kim HS, Her E, Kim YM, Choi WS.
Hypothyroidism protects di(n-butyl)phthalate–induced reproductive organs damage inSprague-Dawleyrats. J. Toxicol. Sci., 33(3) 299-306, 2008.	Lee E, Kim HJ, Im JY, Kim J, Park HY, Ryu JY, Lee J, Shim KA, Jung KK, Han SY, Lee BM, Kim SH, Kim HS.
Increased cytoplasmic levels of CIS, SOCS1, SOCS2, or SOCS3 are required for nuclear translocation. FEBS Letters, 582: 2319-2324, 2008.	Lee KH, Moon KJ, Kim HS, Yoo BC, Park S, Lee H, Kwon S, Lee ES, Yoon S.
Curcumin stimulates proliferation of embryonic neural progenitor cells and neurogenesis in the adult Hippocampus. Journal of Biological Chemistry, 283: 14497-14505, 2008.	Kim SJ, Son TG, Park HR, Park M, Kim MS, Kim HS, Chung HY, Mattson MP, Lee J.
Phorbol ester up-regulate sphospholipase D1 but not phospholipase D2 expression through a PKC/Ras/ERK/NFkB-dependent pathway and enhances matrix metalloproteinase-9 secretion in colon cancer cells. Journal of Biological Chemistry, 283: 4094-4104, 2008.	Kang DW, Park MH, Lee YJ, Kim HS, Kwon TK, Park WS, Min DS.
Radinger M, Her E, Choi WS. Camelliajaponica suppresses immunoglobin E-mediated allergic response by the inhibition of Syk kinase activation in mast cells. Clinical & Experimental Allergy, 38: 794-804, 2008.	Lee JH, Kim JW, Ko NY, Mun SH, Kim DK, Kim JD, Kim HS, Lee KR, Kim YK,
Modulation of cell cycles and apoptosis by apicidinin estrogen receptor (ER)-positive and –negative human breast cancer cells. Chem. Biol. Interact. 172: 235-244, 2008.	Im JY, Park HY, Kang KW, Choi WS, Kim HS.
Effects of apicidin, a histone deacetylase inhibitor, on regulation of apoptosis through the ERK pathway in H-ras-transformed and non-transformed human breast epithelial cells. International Journal of Molecular Medicine, 21: 325-333, 2008.	Park HY, Im JY, Kim J, Choi WS, Kim HS.
A natural histone deacetylase inhibitor, Psammaplin A, inhibits cell proliferation and induces alteration of cell cycle regulators, apoptosis in human endometrial cancer cells. Gynecologic Oncology, 108, 27-33, 2008.	Ahn MY, Na YJ, Jung J, Kim HS.

Polygoni cuspidate radix inhibits the activation of Syk kinase in mast cells for antiallergic activity. Exp. Biol. Med., 232, 1425-1431, 2007.	Lim BO, Lee JH, Ko NY, Mun SH, Kim JW, Kim DK, Kim JD, Kim BK, Kim HS, Her E, Lee HY,Choi WS.
Toxicokinetics of phthalic acid:the common final metabolite of phthalic acid esters in rats. J. Toxicol. Environ. Health Part A, 70(15-16):1344-1349, 2007.	Lim DS, Shin BS, Yoo SD, Kim HS, Kwack SJ, Ahn MY, Lee BM.
Sodium Butyrate Regulates Androgen Receptor Expression and Cell Cycle Arrest in Human Prostate Cancer Cells. Anticancer Research, 27: 3285-3292, 2007.	Kim JA, Park HY, Im JY, Choi WS, Kim HS.
Suppressive effects of bisphenol A on the proliferation of Neural Progenitor Cells. Journal of Toxicology & Environmental Health, 70(15-16), 1288-1295, 2007.	Kim KH, Son TG, Kim SJ, Kim HS, Kim TS, Han SY, Lee JW.
Di(2-ethylhexyl) phthalate induced apoptosis through peroxisome proliferators-activated receptor-gamma and ERK1/2 activation in testis of Sprague-Dawley rats. Journal of Toxicology & Environmental Health, 2007.70(15-16), 1296-1303.	Ryu JY, Hwanf J, Park HY, Im JY, Kim J, Ahn MY, Lee JW, Lee BM, Yoo SD, Kwack SJ, Oh JH, Park KL, Han SY, Kim HS.
Alteration of di(n-butyl)phthalate-induced oxidative stress in the testis of hypothyroid rats. Toxicological and Environmental Chemistry, 2007.	Ryu JY, Lee E, Kim HJ, Park HY, Im JY, Kim J, Han SY, Kang IH, Park KL, Kim HS.
The nuclear localization of SOCS6 requires the N-terminal region and negatively regulates Stat3 protein levels. Biochem. Biophys. Res. Commun. 360:333-338, 2007.	Hwang MN, Min CH, KimHS,LeeH,YoonKA,ParkSY,LeeES.YoonS.
Effect of di(n-butyl) phthalate on testicular oxidative damage and antioxidant enzymes in hyperthyroid rats. Environmental Toxicology, 22(3):245-255, 2007.	Lee E, Ahn MY, Kim HJ, Kim IY, Han SY, Kang TS, Hong JH, Park KL, Lee BM, KimHS.
Identification of differentially expressed genes in the testis of Sprague-Dawley rats treated with di(n-butyl) phthalate. Toxicology, 234:103-112, 2007.	Ryu JY, Lee BM, Kacew S, KimHS.
Assessment of in vitro assay system for thyroid hormone disruptors using rat pituitary GH3 cells. J. Toxicol. Pub. Health, 22: 307-313, 2007.	Kim HJ, Park HY, Kim J, Kang IH, Kim TS, Han SY, Kang TS, Park KL, Kim HS.

Repeated 28-day oral toxicity study of ketoconazole in rats based on the draft protocol for the "Enhanced OECD Test Guideline No. 407" to detect endocrine effects. Arch. Toxicol. 80: 797-803, 2006.	Shin JH, Moon HJ, Kang IH, Kim TS, Kim IY, Park IS, Kim HS,Jeung EB, Han SY.
The Anti-CD25 Monoclonal Antibody 7G7/B6, Armed with the {alpha}-Emitter 211At, Provides Effective Radioimmunotherapy for a Murine Model of Leukemia. Cancer Res. 66:8227-8232, 2006.	Zhang M, Yao Z, Zhang Z, Garmestani K, Talanov VS, Plascjak PS, Yu S, KimHS,GoldmanCK,PaikCH,BrechbielMW,CarrasquilloJA,WaldmannTA.
Genotoxic evaluation of the biocomponents of the cricket, gryllus Bimaculatus, using three mutagenicity tests. J. Toxicol. & Environ. Health, Part A, 68:2111-2118, 2005.	Ahn MY, Bae HJ, Kim IS, Yoo EJ, Kwack SJ, Kim HS, Kim DH, Ryu KS, Lee HS, Kim JW, Kim I, Lee BM.
Age-dependent increases in benzo(a)pyrenediol- epoxide-I-DNA adduct inhumanstomach. J. Toxicol. & Environ. Health, Part A, 68:1599-1610, 2005.	Lee BM, Kwack SJ, Kim HS.
Alteration of cytochrome P450 and glutathione S-transferase activity in normal and malignant human stomach tissues. J. Toxicol. & Environ. Health, Part A, 68: 1611-1620, 2005.	Kim HS, Kwack SJ, Lee BM.
Validation of OECD rodent uterotrophic assay for assessment of estrogenic activity in Sprague-Dawley immature female rats. J. Toxicol. & Environ. Health, Part A, 68: 2249-2262, 2005.	Kim HS, Kang IH, Shin JH, Kim TS, Moon HJ, Kim IY, Seok JH, Park KL and Han SY.
Effects of chemical carcinogen and physicochemical alteration on the UV spectrophotometric determination of DNA. J. Toxicol. & Environ. Health, Part A, 68: 2081-2110, 2005.	Kim HS, Byun SH, and Lee BM.
Neurotoxic effect alcohol and acetaldehyde during embryonic development. J. Toxicol. & Environ. Health, Part A, 68: 2147-2165, 2005.	Lee RD, Kim SS, Kim SH, Shon KH, Kwack SJ, Ahn BS, Kim HS, and Park KL.
Pyrethroid insecticides, fenvalerate and permethrin, exhibit antiestrogenic and antiprogestagenic activities in estrogen receptor positive human breast cancer T47D cells. J. Toxicol. & Environ. Health, Part A, 68: 2175-2186, 2005.	Kim IY, Kim HS, Kim TS, Kang IH, Moon A, Choi KS, Han SY.
Genotoxic evalulation of Isariasinclairii(ISE) extract. J. Toxicol. & Environ. Health, Part A, 67: 2037-2044, 2004.	Ahn MY, Kim HS, Kim IS, Chun SA, Yoo SD, Park YA, Choi SM, Kim KB, Han SY, Park KL, Kwack SJ,Song HS, Lee KR, Bae HJ and Cho MH, Lee BM,
Physiologically-based pharmacokinetics of bisphenol A. J. Toxicol. & Environ. Health, Part A, 67: 1971-1985, 2004.	Shin BS, Park KL, Han SY, Lee BM, Kim HS, Lee KC, Eom HJ, Yoo SD.
Differential gene profiles in developing embryo and fetus alter in utero exposure to ethanol. J. Toxicol. & Environ. Health, Par A, 67: 2073-2081, 2004.	Lee RD, Kim SS, Kim SH, Shon KH, Kwack SJ, An BS, KimHS,andParkKL
Neonatal exposure of DBP inhibits the male rat reproductive organs development. J. Toxicol. & Environ. Health, Part A, 67: 2045-2060, 2004.	Kim HS, Kim TS, Shin JH, Moon HJ, Kang IH, Kim IY, Suk JH and Han SY.
Comparison of anti-androgenic activity of flutamide, vinclozolin, procymidone, linuron, and p,p’-DDE in rodent 10-day Hershberger assay. Toxicology 199:145-159, 2004.	Kim HS, Kang IH, Shin JH, Kim TS, Moon HJ, Kim IY, Seok JH, Park KL and Han SY.
Antiandrogenic activity of phthalate esters (diethylhexyl phthalate, dibutyl phthalate, and butyl benzyl phthalates) in rodent 10-day Hershberger assay using immature castrate male rats. Journal of Toxicology &Public Health, 2003.	Kim HS, Shin JH, Kang IH, Moon HJ, Kim IY, Seok JH, Park KL and Han SY.
Expression of estrogen receptor α and β in the uterus and vagina of immature rats treated with 17-ethinyl estradiol J. Vet. Med. Sci. 65:1293-1297, 2003.	Kang JS, Lee BJ, Ahn B, Kim DJ, Nam SY, Yun YW, Nam KT, Choi M, Kim HS, Jang DD, Lee YS, Yang KH.
Synthesis of dendrimer-based biotin radiopharmaceuticals to enhance whole-body clearance. Nuclear Medicine & Biology 30: 617-625, 2003.	Sato N, Kim HS, Han ES, Wong KJ, Paik RS, Park L, Yao Z, Carrasquillo JA. and Paik CH.
Ras transgene expression in TG-AC mice treated with benzo[a]pyrene. Biological & Pharmaceutical Bulletin, 26: 733-735, 2003.	Lee BM, Kim HS, Kim IS, Ahn MY, Chun SA, Yoo SD, Park YA, Choi SM, Kim KB, Han SY, Park KL, Kwack SJ, Song HS, Lee KR, Bae HJ and Cho MH.
2,3,7,8-tetrachloro-p-dioxin in hibits proliferation of SK-N-SH human neuronal cells through decreased production of reactive oxygen species. Free Radical Research, 36: 1283-1289, 2002.	Lee YS, Jin D-Q, Park SH, Han SY, Kim HS, Jeong TC, Huh K and Kim J-A.
Pharmacokinetics caling of bisphenol A by species-invarianttime methods. Xenobiotica, 32: 925-934, 2002.	Cho CY, Shin BS, Jung JH, Kim DH, Lee KC, Han SY, Kim HS, Lee BM, Yoo SD.
Comparative estrogenic effects of p-nonylphenol by 3-day uterotrophic assay and female pubertal onset assay. Reproductive Toxicology 16: 259-268, 2002.	Kim HS, Shin JH, Moon HJ, Kang IH, Kim TS, Kim IY, Seok JH, Pyo MY and Han SY.
No androgenic/anti-androgenic effects of bisphenol-A Hershberger assay using immature castrated rats. Toxicology Letters 135: 111-123, 2002.	Kim HS, Han SY, Kim TS, Kwack SJ, Lee RD, Kim IY, Seok JH, Lee BM, Yoo SD and Park KL.
Comparative evaluation of alkylphenolic compounds on estrogenic activity in vitro and in vivo. Journal of Toxicology & Environmental Health, Part A 65: 419-431, 2002.	Kwack SJ, Kwon O, Kim HS, Kim SS, Kim SH, Shon KH, Lee RD, Park CH, Jeung EB, An BS and Park KL.
Evaluation of rodent 20-day pubertal female assay in Sprague-Dawley rats treated with DES, tamoxifen, testosterone, and flutamide. Toxicological Sciences 67: 52-62, 2002.	Kim HS, Shin JH, Moon HJ, Kim TS, Kang IH, Seok JH, Kim IY, Park KL and Han SY.
Effects of flutamide on puberty in male rats: an evaluation of the protocol for the assessment of pubertal development and thyroid function. Journal of Toxicology & Environmental Health, Part A 65: 433-445, 2002.	Shin JH, Kim HS, Moon HJ, Kang IH, Kim TS, Seok JH, Kim IY, Park KL,Han SY,Nam SY.
Maternal-fetaldispositionofbisphenolAinpregnantSprague-Dawleyrats. Journal of Toxicology & Environmental Health, Part A 65: 395-406, 2002.	Shin BS, Yoo SD, Cho CY, Jung JH, Lee BM, Kim JH, Lee KC, Han SY, Kim HS and Park KL.
Carcinogen derived from food and food contaminants. Journal of Korean Association of Cancer Prevention. 3: 123-128, 2001.	Kim HS, Hong CM and Kim DJ.
Potential estrogenic effects of bisphenol-A in both in vitro and in vivo combination assays. Journal of Toxicological Sciences 26: 111-118, 2001.	Kim HS, Han SY, Yoo SD, Lee BM, and Park KL.
Bioavailability and mammary excretion of bisphenol A in Sprague-Dawley rats. Journal of Toxicology & Environmental Health, Part A 64: 417-426, 2001.	Yoo SD, Shin BS, Lee BM, Lee KC, Han SY, Kim HS, Kwack SJ and Park KL
Sensitivemicro-sample analysis of Bisphenol A in serum by High-Performance Liquid Chromatography with fluroscence detection. Chromatographia 53: 669-672, 2001.	Shin BS, Park KL, Han SY, Lee BM, Kim HS, Lee KC, Eom HJ, Yoo SD.
Protective effects of antioxidant supplementation on plasma lipid peroxidation in smokers. Journal of Toxicology & Environmental Health, Part A 63: 583-598, 2001.	Kim HS and Lee BM.
Effect of ochratoxin A on cytotoxicity and cell differentiation in cultured rat embryonic cells. Journal of Toxicology & Environmental Health 61, 609-621, 2000.	Hong JT, Park KL, Han SY, Park KS, Kim HS, Oh SD, Lee RD, and Jang SJ.
Lipid peroxidation, antioxidant enzymes, and benzo[a]pyrene-quinones in the blood of rats treated with benzo[a]pyrene. Chemico-Biological Interactions 127, 139-150, 2000.	Kim HS, Kwack SJ and Lee BM.
Inducible nitric oxide synthesis mRNA is upregulated in skin tumors of v-Ha-ras transgenic TG-AC mice treated with 12-O-tetradecanoylphorbol-13-acetate. Biological & Pharmaceutical Bulletin 23, 826-829, 2000.	Lee BM, Kim HS and Jeohn GH.
Pharmacokinetic disposition and tissue distribution of bisphenol A in rats after intravenous administration. Journal of Toxicology & Environmental Health 60, 131-139, 2000.	Yoo SD, Shin BS, Kwack SJ, Lee BM, Park KL, Han SY and Kim HS.
Uterotrophic assay using ovariectomized female rats with sub-cutaneous administration. Journal of Applied Pharmacology 8: 78-83, 2000.	Kim HS, Han SY, Lee RD, Kil KS and Park KL.
Evaluation of in vitro and in vivo screening and testing methods for estrogenic activity of endocrine disruptors. Journal of Toxicology & Public Health 16: 109-116, 2000.	Kim HS, Han SY, Han SK, Park KS, Kim KB, Jang SJ and Park KL.
Dose-Respons echaracteristics of uterotrophic activity in immature female rats by sub-cutaneous injection of estrogen agonist and antagonist. Environmental Mutagens & Carcinogens 20: 1-6, 2000.	Han SY, Kim HS, Lee DH, Oh SD, Kim T. Sand Park KL.
Study on estrogenic activities of phthalate esters using E-screen and competitive binding assay. Journal of Toxicology & Public Health 16: 141-146, 2000.	Han SY, Han SK, Moon HJ, Kim HS, Lee DH, Kim SH, Kim TS and Park KL.
Apoptosis of rat embryonic mid brain cells in ochratoxin A-induced microcephaly. Journal of Food Hygiene & Safety, 15: 41-45, 2000.	Hong JT, Park KL, Han SY, Park KS, Kim HS, Oh SD, Lee RD and Jang SJ.
In vitro chemopreventive effects of plant polysaccharides (Aloe barbadensis Miller, Lentinus edodes, Ganoderma lucidum, and Coriolus vesicolor). Carcinogenesis 20, 124-128, 1999.	Kim HS, Kacew S and Lee BM.
Inhibition of oxidative DNA damage, 8-OHdG, and carbonyl contents in smokers treated antioxidants (vitaminE,vitaminC,β-carotene and red ginseng). Cancer Letters 132, 219-227, 1998.	Lee BM, Lee SK and Kim HS.
Association of Helicobacter pylori Infection with Gastric Adenocarcinoma in Korean. Japanese Journal of Cancer Research 89, 597-603, 1998.	Lee BM, Jang JJ, You JJ, Chun SA, Kim HS, Han HM, Ahn MY and Byun SH.
Benzo(a)pyrene diol-epoxide-I-DNA and oxidative DNA adducts associated with gastric adenocarcinoma. Cancer Letters 125, 61-68, 1998.	Lee BM, Jang JJ and Kim HS.
Inhibition of benzo(a)pyrene-DNA adduct formation by Aloe barbadensis Miller. Carcinogenesis 18, 771-776, 1997.	Kim HS and Lee BM.
Genotoxic Evaluation of Recombinant Human Erythropoietin (rHu-EPO) In Short-term Assays. Environmetal Mutagens & Carcinogens 16: 103-108, 1996.	Kim HS, Kwack SJ, Chun SA, Lim SY, Kim WB, Kim BM, Ahn BO, Suh DS and Lee BM.

B .S.	Bachelor of Pharmacy, Sungkyunkwan University (1985. 03 ~ 1989. 02)
M .S.	Master of Pharmacy, Sungkyunkwan University (1989. 03 ~ 1991. 02)
Ph.D.	Doctor of Pharmacy, Sungkyunkwan University (1992. 03 ~ 1996. 08)

M .S.	Toxic effect of S-bioallethrine in rats (Professor, Sa Uk Hong, Ph.D.)
Ph.D.	Cancer chemopreventive effect of plant polysaccharides on biomarkers associated with multistage carcinogenesis (Professor, Byung Mu Lee, Ph.D.)

2003. 09 ~ 2013. 02	부산대학교 약학대학 교수
2006. 01 ~ 2008. 12	부산대학교 약학대학 부학장
2013. 03 ~	성균관대학교 약학대학 교수
2019. 01 ~	성균관대학교 약학대학 BK21사업단장
2022. 01 ~	성균관대학교 글로벌신약개발연구원 원장

Professor

HyungSik Kim(김형식)

Prof.

Education

B.S.

성균관대학교 약학대학 학사

(1985.03 ~ 1989.02)

M.S.

성균관대학교 약학대학 석사

(1989.03 ~ 1991.02)

Ph.D

성균관대학교 약학대학 박사

(1992.03 ~ 1996.08)

Dissertation Titles

M.S.

Toxic effect of S-bioallerhrine in rats

(Professor, Sa Uk Hong. Ph.D.)

Ph.D

Cancer chemopreventive effect of plant polysaccharides on biolmarkers associated with multistage carcinogenesis

(Professor, Byung Mu Lee. Ph.D.)

Carrer Highlights

부산대학교 약학대학 교수

부산대학교 약학대학 부학장

성균관대학교 약학대학 교수

성균관대학교 약학대학 BK21사업단장

성균관대학교글로벌신약개발연구원 원장

국립독성연구원 독성부

대한약학회 학술간사

환경독성보건학회 학술위원장 / 부회장

한국독성학회/발암원학회 학술위원장

식품위생안전성학회 이사

대한약학회 사업위원장

한국독성학회/발암원학회 사무총장

대한약학회 총무위원장

한국독성학회/발암연구원학회 수석부회장

대한약학회 사무총장

미국 NIH visiting fellow

김형식 교수님

Prof. HyungSik Kim

Education

Dissertation Titles

Carrer Highlights

In Univ.

In Association.

Etc.

Publications.

성균관대학교
글로벌신약개발연구원 원장

한국독성학회/발암연구원학회
수석부회장